Evaluating the costs of cholera illness and cost-effectiveness of a single dose oral vaccination campaign in Lusaka, Zambia

Introduction In 2016, for the very first time, the Ministry of Health in Zambia implemented a reactive outbreak response to control the spread of cholera and vaccinated at-risk populations with a single dose of Shancol—an oral cholera vaccine (OCV). This study aimed to assess the costs of cholera illness and determine the cost-effectiveness of the 2016 vaccination campaign. Methodology From April to June 2017, we conducted a retrospective cost and cost-effectiveness analysis in three peri-urban areas of Lusaka. To estimate costs of illness from a household perspective, a systematic random sample of 189 in-patients confirmed with V. cholera were identified from Cholera Treatment Centre registers and interviewed for out-of-pocket costs. Vaccine delivery and health systems costs were extracted from financial records at the District Health Office and health facilities. The cost of cholera treatment was derived by multiplying the subsidized cost of drugs by the quantity administered to patients during hospitalisation. The cost-effectiveness analysis measured incremental cost-effectiveness ratio—cost per case averted, cost per life saved and cost per DALY averted—for a single dose OCV. Results The mean cost per administered vaccine was US$1.72. Treatment costs per hospitalized episode were US$14.49–US$18.03 for patients ≤15 years old and US$17.66–US$35.16 for older patients. Whereas households incurred costs on non-medical items such as communication, beverages, food and transport during illness, a large proportion of medical costs were borne by the health system. Assuming vaccine effectiveness of 88.9% and 63%, a life expectancy of 62 years and Gross Domestic Product (GDP) per capita of US$1,500, the costs per case averted were estimated US$369–US$532. Costs per life year saved ranged from US$18,515–US$27,976. The total cost per DALY averted was estimated between US$698–US$1,006 for patients ≤15 years old and US$666–US$1,000 for older patients. Conclusion Our study determined that reactive vaccination campaign with a single dose of Shancol for cholera control in densely populated areas of Lusaka was cost-effective.


Introduction
In 2016, for the very first time, the Ministry of Health in Zambia implemented a reactive outbreak response to control the spread of cholera and vaccinated at-risk populations with a single dose of Shancol-an oral cholera vaccine (OCV). This study aimed to assess the costs of cholera illness and determine the cost-effectiveness of the 2016 vaccination campaign.

Methodology
From April to June 2017, we conducted a retrospective cost and cost-effectiveness analysis in three peri-urban areas of Lusaka. To estimate costs of illness from a household perspective, a systematic random sample of 189 in-patients confirmed with V. cholera were identified from Cholera Treatment Centre registers and interviewed for out-of-pocket costs. Vaccine delivery and health systems costs were extracted from financial records at the District Health Office and health facilities. The cost of cholera treatment was derived by multiplying the subsidized cost of drugs by the quantity administered to patients during hospitalisation. The cost-effectiveness analysis measured incremental cost-effectiveness ratiocost per case averted, cost per life saved and cost per DALY averted-for a single dose OCV.

Results
The mean cost per administered vaccine was US$1.72. Treatment costs per hospitalized episode were US$14.49-US$18.03 for patients �15 years old and US$17.66-US$35.16 for older patients. Whereas households incurred costs on non-medical items such as communication, beverages, food and transport during illness, a large proportion of medical costs were borne by the health system. Assuming vaccine effectiveness of 88. 9%

Introduction
Cholera is a significant global health problem and is endemic in Africa and Asia where access to improved water and sanitation is inadequate [1]. It can be acquired through ingestion of food or water contaminated with bacterium Vibrio Cholerae serogroup O1 or O139. Cholera disease is characterized by a sudden onset of acute watery diarrhea that can rapidly lead to death by severe dehydration, if untreated [2,3]. An estimated 1.4 billion people are at risk of cholera worldwide. Of the 132,121 cases reported in 2016, 54% were from Africa, 32% from Hispaniola and 13% from Asia [1,4]. Zambia first reported cholera outbreaks in 1978 and has suffered large cholera epidemics with around 13,000 cases reported in 1991 and over 11,000 in 1992 and 1999 [5]. From 1999 to 2013, major outbreaks have been reported every year in the country's capital, Lusaka [6]. The 2016 outbreak on which this paper is based recorded a total of 1,079 cases and 20 deaths. Lusaka experienced another cholera outbreak in 2017-18 with an estimated 5,414 cumulative cases and a Case Fatality Ratio (CFR) of 1.8% [7][8][9].
Prolonged and frequent outbreaks can be devastating and often dramatically impact economies thereby causing increased expenditure on treatment, declines in income for cholera patients and their households, reduced exports and loss of tourism revenue [10]. In 2005, the 125,018 cases of cholera notified to the World Health Organization (WHO) resulted in a real total economic loss of US$38.9-US$64.2 million [11]. In 1997, the average household and health systems costs of illness per episode were estimated at US$104 as compared to US$43 estimated by hospital-based studies in 2005 [2]. Cost-effective measures to prevent and control cholera should be implemented to mitigate such economic losses.
A multifaceted approach is key to preventing and controlling cholera outbreaks, including improved water, sanitation and hygiene (WASH), health education and promotion, social mobilization, surveillance and timely treatment with Oral Rehydration Salts (ORS), intravenous (IV) fluids, antibiotics and, Zinc supplements for children aged 6 months to 5 years [3, 12,13]. However, since the improvement of WASH remains difficult to achieve in many endemic countries, Oral Cholera Vaccines (OCVs) have been recommended as a supplementary, cost-effective and more immediate option for cholera control and prevention [2,3]. Previous results have demonstrated that OCVs confer significant herd protection over several years [14].
In 2001, the WHO prequalified Dukoral (SBLVaccine, Sweden) for purchase by United Nations (UN) agencies [15]. Since then, several studies have documented the protective effect of OCVs [16][17][18] and the feasibility of mass vaccination campaigns [19,20]. Shancol (Shantha Biotechnics Limited, Hyderabad, India), a killed whole-cell OCV pre-qualified in 2011, is said to be easier to deliver in challenging field conditions and less costly because it does not contain the cholera toxin and does not require co-administration with an oral buffer [15,21].
Vaccine purchase and delivery cost per-double dose of Shancol was estimated at US$0.49-US$0.97 between 2008 and 2016. Similarly, the total cost per fully vaccinated individual was estimated at US$1.13 and increased to US$8.75 in resource-poor settings. In Malawi, the cost of vaccine purchase and shipment per fully vaccinated person was US$5.20 in 2016 and the financial cost for delivering the vaccine was US$1.94. Personnel costs accounted for almost 71% of the total economic costs of vaccine delivery [22].
Assuming 50% vaccine coverage among individuals aged �2years, a reactive vaccination campaign in Zimbabwe could have averted 1,320 deaths and 23,650 Disability Life Adjusted Years (DALYs) in 2008-2009 [23]. Cholera vaccinations among 1-14 year olds every three years would be the most cost-effective, reducing incidence by 45% and costing US$823 for single dose vials per DALY averted as compared to more than 90% reduction in incidence for older persons, but less cost-effective at US$894-US$1,234 per DALY [24].
Even though cholera outbreaks occur periodically in Zambia, there is a dearth of information on the costs of cholera illness and cost-effectiveness of OCV campaigns. The purpose of this study was to assess the cost of cholera illness from a household and health system perspective and determine if the single dose OCV campaign that was implemented for the first time in response to the 2016 cholera outbreak in Lusaka was cost-effective. As the country structures ongoing efforts towards developing comprehensive and integrated plans for controlling and preventing future cholera outbreaks, the results of this analysis could help the Ministry of Health (MoH) to decide whether or not to use OCVs as a reactive measure.

Study design and setting
This retrospective cost and cost-effectiveness study was conducted in Lusaka's Bauleni, Chawama and Kanyama compounds, densely populated peri-urban areas with high cholera incidence. Between April and June 2017, we conducted interviews with participants identified from health facility registers. Costs were collected retrospectively from financial records at health facilities and the Lusaka District Health Office (LDHO).
The City of Lusaka is situated in the central part of Zambia on the Central African plateau and lies 1,280 meters above sea level with a surface area of 360 square kilometers. It has a population density of 5,328 persons per square kilometer and an estimated total population of 1.9 million [25]. Health care needs of residents are catered for by public and private health facilities. In the event of a cholera outbreak, specific public health facilities become designated Cholera Treatment Centres (CTCs)-specialized isolation wards for cholera patients.
The 2016 cholera outbreak affected populations in nine peri-urban locations in Lusaka district after a four-year absence, prompting increased concern over vulnerability to infection of approximately 600,000 people living in unsanitary conditions. To prevent further transmission of cholera and shorten the duration of the epidemic, the MoH with support from Médecins Sans Frontières (MSF) and the WHO, mounted a reactive outbreak response using community-based mass vaccination campaigns and vaccinated 424,100 (73.4%) persons aged one year and older with a single dose of Shancol [26]. The OCV was used as a supplement efforts to improve water availability and quality.

Data collection procedures
A research team consisting of an investigator and six Research Assistants (RAs) collected costs incurred by households and the health system. The RAs were trained for two days and provided with Standard Operating Procedures (SOPs) containing step-by-step instructions on how to administer the questionnaires to patients or their caregivers and health care providers and extract data from identified sources. Table 1 summarises expenditure variables and sources of health system, household and vaccine delivery and campaign costs.
To enable mobile collection of data, forms were created in .xml using Open Data Kit (ODK), an open-source suite of tools, and loaded onto tablets before interviews were held with patients or caregivers and health care workers. For quality improvement purposes, both the household and health facility questionnaires were piloted with selected patients or caregivers and health care workers. Prior to the interviews, written informed consent was obtained from health care providers, patients or caregivers (for patients aged below 18 years). At the end of each interview, forms were reviewed for accuracy and completeness before being committed to a central server. Since data were collected more than four months after the identified patients had been treated for cholera and discharged from a CTC, out-of-pocket costs provided by interviewees were verified with reliable sources such as drug catalogues, public transportation fare charts and vendors' price lists.
Household costs of cholera. To determine the sample size for estimating out-of-pocket costs, a standard deviation of US$40 was estimated as the mean household cost for treating cholera. The following formula was applied: n¼4ðstandard deviationÞ 2 =a 2 with a¼6 ½2�: A systematic random sample of 189 (60, 67 and 62 from Bauleni, Chawama and Kanyama health centres, respectively) patients were selected from the 1,079 patients confirmed to have V. cholera 01 or 0139 by culture of a stool specimen. Patient information was extracted for every 5 th patient admitted to a CTC and documented in a register.
Community Health Workers (CHWs-members of the community who often voluntarily support trained health workers and provide basic health care to communities) contacted the identified patients and scheduled appointments for one-on-one interviews at the patient's home or a place of the patient's convenience. On a subsequent day, a research team met the patients as scheduled and obtained direct and indirect costs using the closed-ended household questionnaire. If the identified patient was below 18 years of age, a caregiver was interviewed. OCV vaccine delivery and campaign costs. Due to unavailability of sufficient doses in the global emergency stockpile to cover the entire at-risk population, a single-dose of Shancol was administered to people living in the most affected peri-urban areas [27]. Vaccination delivery and campaign costs were therefore collected for a single dose OCV. Costs were obtained from the LDHO and MSF since they had provided financial and technical support for the mass vaccination campaign. The costs derived by Poncin et al., 2018 have been used to provide estimates of the costs of vaccine delivery and mass vaccination campaign as incurred by MSF [26].
Health systems costs of cholera. To estimate costs from a health system perspective, a research team interviewed nurse-midwives, medical doctors or Environmental Health Technicians (EHTs-staff working in health facilities to identify and rectify environmental health issues) working at CTCs and the LDHO. Staff at the LDHO were interviewed about central level costs. Staff at CTCs provided information on procedures for setting up CTCs and managing hospitalised cholera patients. Using an ingredients-based approach, direct and indirect costs were extracted from financial records and cash registers at health facilities and the LDHO [28]. Patient records were reviewed for length of hospital stay and drugs administered to patients during hospitalisation and after discharge. Costs of drugs were obtained from the Medical Stores Limited (MSL)-an autonomous government agency that provides drugs to public health facilities at a subsidised price [29].
Cost-effectiveness analyses. This study used the Vaccine Introduction Cost-effectiveness (VICE) calculator to estimate the cost-effectiveness of the 2016 OCV campaign with a single dose of Shancol. The VICE calculator is a Microsoft Excel-based tool that was specifically developed to simplify the estimation of cost-effectiveness of OCVs in various settings by using variables that influence the cost-effectiveness of the vaccine. It is capable of highlighting important nuances when different values for individual variables are entered and automatically calculates cost-per-DALY averted, cost per-case-averted and cost-per-death averted [30]. To calculate the resulting ICERs, standardized parameters such as disability weights, discount rate, case fatality ratio (CFR), GDP and vaccine protection in Zambia [31] and Haiti [3,32] were obtained from literature [18]. Other parameters including length of hospital stay, duration of illness, incidence, CFR and treatment costs were derived from this analysis. In place of age weights, a single, homogeneous population was used to compute the cost-effectiveness measures.
In Zambia, as is the case in other countries, drugs are administered to hospitalized cholera patients according to age and severity of infection. Treatment costs were therefore computed for two categories of patients-pediatric patients (�years old) and older patients (�15 years) [1,33]-and used as base-estimates for calculating ICERs. The analysis used Zambia's specific life expectancy (LE) as derived by the World Bank Group [34].
The primary outcome measures of the cost-effectiveness analysis (CEA) were ICERs per DALY averted, per case and death averted. The net vaccination cost was used as the numerator of the ICER and was calculated by subtracting the costs of illness averted from the total vaccination costs at a discount rate of 3% [17]. To be considered cost-effective, derived costs per DALYs averted should have been less than three times the country's GDP per capita valued of $1,500 in 2016 [28,30,33,34,35]. Table 2 shows parameter values assumed for computing the cost-effectiveness of a vaccination campaign using a single dose of Shancol.
To determine the effects of changes in direct cost of treatment, days of illness, GDP, vaccine efficacy, duration of protection and vaccine purchase price on cost-effectiveness, sensitivity analysis was performed using Microsoft Excel (MS Excel, 2016).

Data management and analysis
This study used a cost of illness approach forwarded by Rice [37] and adopted the six suggested cost components for analysing costs of cholera in the WHO African Region which include: (1) hotel, hospital and health centre costs; administration, health personnel remunerations, in-service training, per diem and transport, materials, utilities (electricity, water, telephone and postage), maintenance (of vehicles, equipment and buildings), and capital costs; (2) diagnosis, (3) medicines, (4) costs borne by households, (5) productivity losses, and (6) other losses [10].
The Choltool, a standardised Microsoft Excel-based cholera cost calculator developed by International Vaccine Institute (IVI) [38,39], was adapted for estimating vaccine delivery, mass vaccination campaign and health systems costs. Costs incurred by households and the health system were collected in local currency units (LCUs) and converted to United States Dollars (US$) using the exchange rate at midpoint of 2016. The values were adjusted for inflation. Household and health system data were analysed using Stata 14.2 (StataCorp, College Station, Texas, USA).

Ethics statement
This study protocol was approved by the University of Zambia Biomedical Research Ethics Committee (UNZA BREC-Reference Number 017-10-16) and the Zambia National Health Research Authority (ZNHRA). Permission to visit the health facilities was obtained from MoH and LDHO. Study participants were not given any incentives for participation. Individual written informed consent was obtained from all participants. All data were handled with strict confidentiality and de-identified by assigning individual unique identifiers before data was analysed.

Household costs during hospitalisation
During hospitalisation, a few households reported paying for direct medical costs such as consultation (1.1%), drugs (0.5%) and laboratory tests (0.5%). The remaining households incurred non-medical costs, including communication (12.2%), food and beverages (14.8%) and transport (56.1%). Only a small proportion of respondents spent between US$9.8 and US$48.41 on transport (4.8%) and cell phone calls (2.1%). None of the respondents spent above US$96.81. Table 4 represents costs incurred during hospitalization.

Productivity losses
The majority of patients 134 (70.9%) stayed in hospital for 1 to 3 days while only 8 (4.2%) were admitted for more than seven days. At least 85 (45.0%) of the patients reported another 1-3 days of inactivity after being discharged from a CTC while only 13 (6.9%) said they were inactive for more than seven days. A total of 29 (15.3%) performed their normal activities immediately after discharge. Even though 123 (65.1%) households engaged helpers during the course of a member's illness, only 2 (1.1%) paid US$0.1-US$9.7 for help rendered. To cope with lost income during illness, at least 53 (28%) of the households used their savings, 2.6% sold livestock and household assets, 31 (16.4%) borrowed money and 26 (13.8%) reduced their expenses (Table 5).

Vaccine delivery and OCV campaign costs
Vaccine delivery and campaign costs consisted of consumables, Information, Education and Communication (IEC) materials, vaccine purchase, insurance, shipment, storage, social mobilisation, staff allowances and trainings. The largest proportion of costs were reported for purchase of vaccines (80.2%) and staff incentives (6.7%). Other costs were reported as almost equally distributed among other items, including shipment (2.0%), vaccination consumables (2.6%), social mobilisation (1.6%), and transport (3.2%) [26].

Health systems costs
The analysis in Table 6 shows that the largest proportion of costs incurred by health system was for the purchase of disinfectants (20.7%), followed by laboratory supplies (16.4%) and then drugs and ward supplies (16.1%). Other costs were distributed between personal protective clothing (14%), water sampling kits (5.7%) and miscellaneous items (8.5%). For patients �15, the average cost of treating one episode of cholera with recommended dosage of ORS, IVs, zinc supplement and antibiotics was US$14.49 (with erythromycin),

Cost-effectiveness analysis
Of the 598,131 doses purchased and delivered locally at an estimated cost of US$1.72 per dose (US$1.31 and US$0.41 for purchase and local delivery cost of per dose, respectively), 424,100 were administered against an estimated target population of 578,043. Vaccine coverage was therefore estimated to be 73.4% [26]. Assuming a vaccine effectiveness of 63%, more (317) doses of vaccines would be required to avert a case of cholera as compared to 225 doses at a higher vaccine effectiveness of 89%. Similarly, the number of doses required to avert a case of death due to cholera was estimated at 16,708 doses at a lower vaccine effectiveness of 63% as compared to 11,841 doses at 89%. However, more cases and deaths (1,885) would be averted at 89% vaccine effectiveness as compared to 1,335 cases and deaths at 63%. Whereas only 706 DALYs would be averted on the basis of 63% vaccine effectiveness, 996 would be averted at 89%. Supposing a life expectancy of 62 years and only one campaign every two years [40], the cost of a mass vaccination campaign with a single dose of Shancol was estimated at US$729,452 minus local delivery costs. When compared to the country's GDP per capita threshold of US $1,500, the cost per DALY averted was less and estimated US$556-US$764 for patients �15 years old and US$516-US$765 for patients �15 years old. Computed costs per case averted were US$369-US$532 for patients �15 years old and US$352-US$528 for patients �15 years old. Table 7 shows the results of the CEA of the 2016 vaccine delivery campaign.

Discussion
While some studies report vaccine delivery costs disaggregated by activities, several others disaggregate costs by inputs such as vaccine purchase, shipment, insurance, cold chain management, Costs of cholera illness and cost-effectiveness of a single dose vaccination campaign in Lusaka, Zambia personnel incentives, training, transportation, social mobilization and local delivery. The delivery costs of OCVs via mass campaigns differ by country and even within the same country and the same setting [20,[41][42][43][44][45]. The variations in cost estimates could considerably impact the scale up of OCV campaigns to prevent cholera outbreaks, hence the need to ascertain associated costs for individual settings.
In 2016, a study evaluated the feasibility of conducting a large-scale reactive cholera vaccination campaign in high-risk peri-urban areas of Lusaka and showed that a single dose of Shancol was purchased at US$1.31 and delivered to the community at US$0.41 per vaccine [26]. Therefore, about US$1.72 was spent per vaccinated person, 80% of which was attributed to vaccine purchase. In Hue City, Vietnam, the cost per vaccinated person was lower and estimated at US$1.07 with a higher proportion (90%) of the cost being spent on purchasing the vaccine [46]. Even though only a single dose was administered to 73.4% of targeted persons, the total cost of implementing the OCV campaign was somewhat high and estimated at US $1,152,291, including costs for local delivery for 578,043 doses. The total cost of implementing an OCV campaign could increase supposing all eligible residents in a cholera prone area were vaccinated with recommended doses of OCV. However, integrating mass vaccinations into the health system and conducting OCV campaigns routinely could marginally reduce costs [19].
Studies have reported higher incidence of cholera in households whose water source was not potable or did not have an in-house stand pipe [33]. In this study, about 75% of households which recorded a cholera case obtained their water from a public piped water source. The costs of improving WASH were not collected and can therefore not be compared with the costs of implementing OCVs. However, although cholera vaccination benefits individuals with potential herd immunity for the larger community, relevant authorities should consider prioritising surveillance and improving water supply and quality to prevent future cholera outbreaks [18].
In Zambia, cholera treatment is provided free of charge in public health facilities. Consequently, a large proportion of the total expenditure amounting to US$687,939 was borne by the health system and attributed to the purchase of medical supplies such as disinfectants, drugs, laboratory and ward supplies. This is consistent with other studies that reported that health care provider costs account for the largest proportion of costs [33,45]. However, in cases where patients had incurred costs, a large proportion of them were attributed to out-ofpocket costs and productivity losses [1]. Transport, communication and food and beverage costs were the major drivers for household costs contrary to other reports which attributed the highest costs to treatment of cholera [47]. The high expenditure on transport was attributable to distance and travel time from a patient's house to the CTC [48,49].
Based on prescribed guidelines for treating cholera patients of different age groups, this paper considers treatment costs and vaccine effectiveness as key variables for calculating ICERs. Other studies have disregarded vaccine efficacy and demonstrated cost-effectiveness of OCV in endemic settings using cholera incidence and cost of vaccine as key variables [50].
Since the cost of treating cholera patients was based on two age groups, treatment costs per hospitalised patient with an episode of cholera were estimated US$14.77-US$ 18.03 for children �15 years old as compared to US$17.66-US$35.16 for older patients. In this study, the costs were highest for episodes treated with recommended doses of rehydration solutions, IV fluids, zinc supplement and erythromycin antibiotic. Corresponding costs for treating adults were similar in Beira, Mozambique (US$18.80) and Kolkata, India (US$17.90) but much higher in North Jakarta, Indonesia (US$134.00) [35]. Other studies have applied an average cost of treating hospitalized cases to all age groups [1]. Assuming two different vaccine effectiveness rates, the derived treatment costs were used to calculate the total cost per DALY averted for the two age groups.
This study demonstrates that vaccinating a single homogeneous population at risk of cholera disease is cost effective. These results are contrary to findings that suggest that vaccination programs that include adults can generally be less cost-effective than interventions targeted at all eligible children [18]. The costs per case averted during the 2016 OCV campaign were higher and estimated at US$369-US$532 for children �15 years old as compared to US$352-US$528 for older patients. This was similar to findings documented by Khan et al., 2018 that showed that varying costs of treatment do not substantially change the resulting ICERs [50].
Costs per case averted declined from US$699-US$666 for patients �15 years old and US $705-US$698 for patients �15 particularly when a higher vaccine effectiveness of 89% was used as a parameter to compute cost-effectiveness. Assuming a lower vaccine effectiveness of 63%, the total cost per DALY averted increased with a decrease in the cost of treatment. A study conducted in endemic settings demonstrated that the cost per case averted and per hospitalization averted declines with increasing cholera incidence, hence a very inexpensive vaccine becomes cost-effective only when incidence exceeds 1/1000 [51].
The results presented in this paper are unique because they include estimates of vaccine delivery and campaign costs, out-of-pocket and health systems costs and cost-effectiveness analysis of the vaccination campaigns with a single dose of Shancol a in peri-urban setting. Data from other studies were skewed towards adult hospitalised men and did not collect costs related to productivity losses for patients who had suffered cholera disease [33,45].

Limitations
Outbreak driven diseases often have considerable costs that may not be associated with providing patient care. Such costs may be problematic to collect. For instance, this study did not calculate costs associated with loss of tourism due to the cholera outbreak or movement of economic activity from a cholera affected area to a non-affected area. Neither did we estimate time and money incurred by households on acquiring vaccines, loss of income due to stigma suffered by cholera patients nor costs of burying deceased cholera patients.
In addition, the analysis did not estimate health care provider costs associated with shifting of health funds and staff from routine services to outbreak management. The data presented in this paper may have been affected by patients' recall bias since they were collected almost four months after patients had been treated for cholera.
The VICE calculator assumes that vaccines were administered to different groups with different characteristics. The tool allows users to divide populations into up to four groups (but total distribution should be 100%) or use a whole proportion. The proportions provided across each age category will be added together to get the resulting Total DALYs Averted. For this study, however, we were not able to divide the recipients of the OCV into groups as ages for the total number of people vaccinated was not available from the district health office. We therefore used one proportion (100%) for all age groups, hence the same DALYs averted in both groups. Drug costs are not based on the same sample of patients who were identified to provide costs incurred during cholera disease.
Lastly, the CFR is at least three times as high as in the overall outbreak and therefore suggests that the patients interviewed could have been sicker than the average patient during the outbreak, and likely incurred higher costs. This could have led to an overestimation of the CE of the vaccine.

Conclusions
In conclusion, a cost-effectiveness analysis based on defined vaccine effectiveness and treatment costs shows that a vaccination campaign using a single dose of Shancol among a single, homogeneous population is very cost effective. However, policy makers must consider other budgetary and logistical factors such as vaccine purchase and delivery, personnel training, distribution of Information, Communication and Education (IEC) materials before deciding to introduce OCVs as a control measure for cholera. Since this CEA was based on a single dose OCV, costs of may be significantly higher if two doses were to be administered within recommended time intervals.