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Ian H. Plummer, Chad J. Johnson, Alexandra R. Chesney, Joel A. Pedersen, Michael D. Samuel
Mineral licks as environmental reservoirs of chronic wasting disease prions
www.plosone.org
www.plosone.org
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(23)Tj
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()Tj
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(26)Tj
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(27)Tj
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()Tj
0.83 0.64 0.02 0 k
(29)Tj
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3.3278 0 Td
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([)Tj
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(30)Tj
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()Tj
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(31)Tj
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([)Tj
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(32)Tj
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1.389 0 Td
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(34)Tj
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(].)Tj
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3.4185 0 Td
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[()]TJ
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2.3413 0 Td
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3.3279 0 Td
([)Tj
0.83 0.64 0.02 0 k
(35)Tj
0 g
()Tj
0.83 0.64 0.02 0 k
(37)Tj
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(].)Tj
3.5433 0 Td
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3.4072 0 Td
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2.0126 0 Td
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3.7814 0 Td
(or)Tj
1.0941 0 Td
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4.0761 0 Td
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3.3336 0 Td
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3.8607 0 Td
(that)Tj
1.7802 0 Td
(attract)Tj
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(wildlife)Tj
3.1691 0 Td
(and)Tj
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1.0261 0 Td
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(their)Tj
-35.3307 -1.2982 Td
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5.4424 0 Td
(nutrient)Tj
3.5035 0 Td
(requirements)Tj
5.5616 0 Td
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1.1849 0 Td
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4.6884 0 Td
(soil)Tj
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(and)Tj
1.7291 0 Td
(water)Tj
2.4321 0 Td
([)Tj
0.83 0.64 0.02 0 k
(38)Tj
0 g
(].)Tj
2.0749 0 Td
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2.177 0 Td
(may)Tj
1.9276 0 Td
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-32.3203 -1.3039 Td
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2.3414 0 Td
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2.0295 0 Td
(0.5)Tj
1.3947 0 Td
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1.1791 0 Td
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1.0148 0 Td
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1.6044 0 Td
(monthly)Tj
3.6226 0 Td
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2.2054 0 Td
(licks)Tj
2.0126 0 Td
([)Tj
0.83 0.64 0.02 0 k
(39)Tj
0 g
(].)Tj
2.0749 0 Td
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1.7858 0 Td
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1.5307 0 Td
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1.0148 0 Td
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3.3335 0 Td
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2.0126 0 Td
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1.9673 0 Td
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(other)Tj
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(species,)Tj
3.2201 0 Td
(and)Tj
1.7291 0 Td
(the)Tj
1.474 0 Td
(continuous)Tj
4.7337 0 Td
(deposition)Tj
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2.7893 0 Td
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1.3776 0 Td
(saliva,)Tj
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(feces)Tj
2.143 0 Td
(and)Tj
1.7291 0 Td
(urine)Tj
2.3584 0 Td
(from)Tj
2.2054 0 Td
(infected)Tj
3.4185 0 Td
(ani-)Tj
-35.2796 -1.2983 Td
(mals)Tj
2.0806 0 Td
([)Tj
0.83 0.64 0.02 0 k
(18)Tj
0 g
()Tj
0.83 0.64 0.02 0 k
(19)Tj
0 g
(,)Tj
0.83 0.64 0.02 0 k
(22)Tj
0 g
(,)Tj
0.83 0.64 0.02 0 k
(40)Tj
0 g
()Tj
0.83 0.64 0.02 0 k
(41)Tj
0 g
(])Tj
7.1431 0 Td
(suggests)Tj
3.481 0 Td
(mineral)Tj
3.3278 0 Td
(licks)Tj
2.0183 0 Td
(may)Tj
1.9275 0 Td
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1.0148 0 Td
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4.286 0 Td
(focal)Tj
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(points)Tj
2.7212 0 Td
(for)Tj
1.3833 0 Td
(environ-)Tj
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(transmission)Tj
5.3631 0 Td
(of)Tj
1.0148 0 Td
(CWD.)Tj
2.8119 0 Td
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4.354 0 Td
(little)Tj
1.9956 0 Td
(is)Tj
0.8504 0 Td
(known)Tj
3.0047 0 Td
(about)Tj
2.4944 0 Td
(whether)Tj
3.4753 0 Td
(mineral)Tj
3.3335 0 Td
(licks)Tj
2.0126 0 Td
(serve)Tj
2.2507 0 Td
(as)Tj
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(reservoirs)Tj
4.1328 0 Td
(for)Tj
1.3833 0 Td
(CWD)Tj
2.5851 0 Td
(prions)Tj
2.795 0 Td
(or)Tj
1.0941 0 Td
(their)Tj
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(importance)Tj
4.8302 0 Td
(in)Tj
1.0375 0 Td
(CWD)Tj
2.5851 0 Td
(transmission)Tj
5.3632 0 Td
(among)Tj
2.9933 0 Td
(cervids,)Tj
3.2769 0 Td
(other)Tj
-34.1855 -1.2982 Td
(wildlife,)Tj
3.3958 0 Td
(and)Tj
1.7292 0 Td
(domestic)Tj
3.8493 0 Td
(animals.)Tj
3.5546 0 Td
(This)Tj
1.9842 0 Td
(lack)Tj
1.8199 0 Td
(of)Tj
1.0148 0 Td
(knowledge)Tj
4.5467 0 Td
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(due)Tj
1.7008 0 Td
(primarily)Tj
3.9685 0 Td
(to)Tj
1.0261 0 Td
(the)Tj
1.4684 0 Td
(absence)Tj
3.3392 0 Td
(of)Tj
-34.2422 -1.2983 Td
(practical)Tj
3.6339 0 Td
(and)Tj
1.7292 0 Td
(sensitive)Tj
3.6282 0 Td
(methods)Tj
3.685 0 Td
(to)Tj
1.0205 0 Td
(test)Tj
1.6044 0 Td
(putative)Tj
3.4412 0 Td
(environmental)Tj
6.1115 0 Td
(sources.)Tj
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4.0762 0 Td
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1.0375 0 Td
(highly)Tj
-33.3861 -1.3039 Td
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3.6226 0 Td
[()12()]TJ
1.0148 0 Td
[(\r)-13()14()7()20()]TJ
/F5 1 Tf
2.0466 0 Td
(assays)Tj
2.6248 0 Td
(\(e.g.,)Tj
2.1259 0 Td
(protein)Tj
3.1521 0 Td
(misfolding)Tj
4.5184 0 Td
(cyclic)Tj
2.4605 0 Td
(amplification,)Tj
5.76 0 Td
(PMCA\))Tj
3.3618 0 Td
(have)Tj
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3.9344 0 Td
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1.0148 0 Td
(small)Tj
2.33 0 Td
(amounts)Tj
3.7133 0 Td
(of)Tj
1.0148 0 Td
(CWD)Tj
2.5852 0 Td
(prions)Tj
2.795 0 Td
(in)Tj
1.0374 0 Td
(a)Tj
0.652 0 Td
(variety)Tj
2.9253 0 Td
(of)Tj
1.0148 0 Td
(biological)Tj
4.0876 0 Td
(matrices)Tj
3.6169 0 Td
([)Tj
0.83 0.64 0.02 0 k
(42)Tj
0 g
()Tj
0.83 0.64 0.02 0 k
(44)Tj
0 g
(].)Tj
3.549 0 Td
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-34.2705 -1.2982 Td
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4.5183 0 Td
(cyclic)Tj
2.4547 0 Td
(amplification)Tj
5.5389 0 Td
(relies)Tj
2.3131 0 Td
(on)Tj
1.2755 0 Td
(the)Tj
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1.4684 0 Td
[()12()]TJ
1.0148 0 Td
[(\r)-13()14()7()20()]TJ
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2.0466 0 Td
(conformational)Tj
6.4176 0 Td
(conversion)Tj
4.6318 0 Td
(of)Tj
1.0147 0 Td
(the)Tj
1.4741 0 Td
(normal,)Tj
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(benign)Tj
2.9763 0 Td
(prion)Tj
2.4321 0 Td
(protein)Tj
3.152 0 Td
(\(PrP)Tj
ET
Q
q
1 j
1 J
0 w
7.4999 0 0 6.6659 303.9307 139.8614 cm
BT
/F5 1 Tf
1 TL
-0.0053 Tc
0 0 Td
(C)Tj
ET
Q
q
1 j
1 J
0 w
10 0 0 10 308.9196 135.3826 cm
BT
/F5 1 Tf
1 TL
-0.004 Tc
0 0 Td
(\))Tj
0.5555 0 Td
(to)Tj
1.0262 0 Td
(a)Tj
0.6576 0 Td
(proteinase)Tj
4.371 0 Td
(K)Tj
0.8901 0 Td
(\(PK\)-resistant)Tj
5.8506 0 Td
(form)Tj
2.2054 0 Td
(\(PrP)Tj
ET
Q
q
1 j
1 J
0 w
7.4999 0 0 6.6659 482.7401 139.8614 cm
BT
/F5 1 Tf
1 TL
-0.0053 Tc
0 0 Td
(res)Tj
ET
Q
q
1 j
1 J
0 w
10 0 0 10 491.4141 135.3826 cm
BT
/F5 1 Tf
1 TL
-0.004 Tc
0 0 Td
(\))Tj
0.5612 0 Td
(as)Tj
1.0148 0 Td
(catalyzed)Tj
3.8721 0 Td
(by)Tj
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4.1329 0 Td
(prions.)Tj
3.016 0 Td
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0.9014 0 Td
(sample)Tj
3.0217 0 Td
(putatively)Tj
4.1443 0 Td
(containing)Tj
4.5297 0 Td
(PrP)Tj
ET
Q
q
1 j
1 J
0 w
7.4999 0 0 6.6659 412.3275 126.822 cm
BT
/F5 1 Tf
1 TL
-0.0053 Tc
0 0 Td
(CWD)Tj
ET
Q
q
1 j
1 J
0 w
10 0 0 10 432.2267 122.4 cm
BT
/F5 1 Tf
1 TL
-0.004 Tc
0 0 Td
(is)Tj
0.8503 0 Td
(placed)Tj
2.795 0 Td
(in)Tj
1.0318 0 Td
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1.2019 0 Td
(excess)Tj
2.6815 0 Td
(of)Tj
1.0148 0 Td
(PrP)Tj
ET
Q
q
1 j
1 J
0 w
7.4999 0 0 6.6659 542.8346 126.822 cm
BT
/F5 1 Tf
1 TL
-0.0053 Tc
0 0 Td
(C)Tj
ET
Q
q
1 j
1 J
0 w
10 0 0 10 550.0346 122.4 cm
BT
/F5 1 Tf
1 TL
-0.004 Tc
0 0 Td
(and)Tj
1.7291 0 Td
(is)Tj
-36.731 -1.2982 Td
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3.9684 0 Td
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1.0262 0 Td
(repeated)Tj
3.6396 0 Td
(cycles)Tj
2.5512 0 Td
(of)Tj
1.0148 0 Td
(sonication)Tj
4.3823 0 Td
(and)Tj
1.7292 0 Td
(incubation)Tj
4.5467 0 Td
(to)Tj
1.0261 0 Td
(amplify)Tj
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(the)Tj
1.4684 0 Td
(amount)Tj
3.3562 0 Td
(of)Tj
1.0148 0 Td
(PrP)Tj
ET
Q
q
1 j
1 J
0 w
7.4999 0 0 6.6659 544.6488 113.8393 cm
BT
/F5 1 Tf
1 TL
-0.0053 Tc
0 0 Td
(res)Tj
ET
Q
q
1 j
1 J
0 w
10 0 0 10 553.2661 109.4173 cm
BT
/F5 1 Tf
1 TL
-0.004 Tc
0 0 Td
(.)Tj
0.4478 0 Td
(Sen-)Tj
-35.7729 -1.3039 Td
(sitivity)Tj
2.8857 0 Td
(is)Tj
0.8504 0 Td
(enhanced)Tj
4.0762 0 Td
(by)Tj
1.1792 0 Td
(replenishing)Tj
5.1873 0 Td
(the)Tj
1.474 0 Td
(supply)Tj
2.8403 0 Td
(of)Tj
1.0148 0 Td
(PrP)Tj
ET
Q
q
1 j
1 J
0 w
7.4999 0 0 6.6659 410.0031 100.8566 cm
BT
/F5 1 Tf
1 TL
-0.0053 Tc
0 0 Td
(C)Tj
ET
Q
q
1 j
1 J
0 w
10 0 0 10 417.1464 96.3779 cm
BT
/F5 1 Tf
1 TL
-0.004 Tc
0 0 Td
(and)Tj
1.7347 0 Td
(subjecting)Tj
4.2973 0 Td
(the)Tj
1.4684 0 Td
(sample)Tj
3.0217 0 Td
(to)Tj
1.0261 0 Td
(further)Tj
-33.2614 -1.2982 Td
(rounds)Tj
3.0614 0 Td
(of)Tj
1.0148 0 Td
(cyclical)Tj
3.1408 0 Td
(sonication)Tj
4.3823 0 Td
(and)Tj
1.7291 0 Td
(incubation)Tj
4.5468 0 Td
(\()Tj
0.83 0.64 0.02 0 k
(Fig)Tj
1.8198 0 Td
(1)Tj
0 g
(\).)Tj
ET
Q
q
1 j
1 J
0 w
576 737.1 m
36 737.1 l
36 737.6 l
576 737.6 l
f*
36 741.2598 107.1496 23.6976 re
W* n
q
107.0929 0 0 23.6409 36 741.3165 cm
q
/I0 Do
Q
Q
Q
q
0 0 612 792 re
W* n
1 j
1 J
0 w
7.9999 0 0 7.9999 488.1826 745.7952 cm
BT
/F0 1 Tf
1 TL
-0.005 Tc
0 0 Td
(Prions)Tj
2.9976 0 Td
(in)Tj
0.9851 0 Td
(the)Tj
1.5803 0 Td
(environme)Tj
4.5851 0 Td
(nt)Tj
ET
Q
q
1 j
1 J
0 w
36 48.0002 m
576 48.0002 l
576 47.5002 l
36 47.5002 l
f*
0.83 0.64 0.02 0 k
81.5811 34.9228 m
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