Correction: Sequence variation in Plasmodium falciparum merozoite surface protein-2 is associated with virulence causing severe and cerebral malaria

[This corrects the article DOI: 10.1371/journal.pone.0190418.].

a Position relative to the first nucleotide / aa. of each block (Fig 2). b In case of SNPs, alleles found in the msp2 sequence of K1 (FC27-liked) (M59766.1) / another found in our data set was shown and amino acid (aa.) changes were indicated.
c Variation in number of repeat 1 and 2 [(R1)n(R2)n] generated 5 distinct alleles in block 3, while 13 alleles were detected when sequence variation in repeat units were considered [R1xR2]. d Allele frequencies were compared between mild (M) and severe (S), mild and cerebral (C), as well as severe and cerebral. For bi-allelic polymorphisms, the odds ratio (OR) of a minor-frequency allele for risk to severe and cerebral malaria by comparing to a major allele was analyzed.
For polymorphisms with more than 2 alleles, the presence or absence of individual alleles were compared. OR and P-values are shown, with significant values in red bold. NA. (not applicable) indicates bi-allelic polymorphisms with minor allele frequency <10% and individual alleles having frequencies <10% or >90%, in which their associations with malaria severity were not analyzed. OR was undefined in cases of zero cell count.
b Major haplotypes (frequency ≥ 10%) observed in the parasite population that were analyzed for association with malaria severity.
c Haplotype frequencies were compared between mild (M) and severe (S), mild and cerebral (C), and severe and cerebral. P-value and Odds ratios (OR) are shown, with statistically significant differences in red bold. NA. (not applicable) indicates haplotypes with frequencies >10% whose association with malaria severity was not analyzed. OR was undefined in cases of zero cell count.  a Position relative to the first nucleotide / aa. of each block (Fig 3) b In case of SNPs, alleles found in the msp2 sequence of 3D7 (PFB0300c) / another allele found in our data set was shown, and amino acid (aa.) changes are indicated.
c For The R1 region in block 3, sequences can be grouped into nine types according to the presence of different types of numerically coded dipeptide motifs (Table S1).
d For the R2 region, there were 8, 11, and 14 Threonine repeats encoded by 2-4 copies of nanomer (ACT ACC ACA) followed by ACT ACT.
e Allele frequencies were compared between mild (M) and severe (S), mild and cerebral (C), and severe and cerebral. For bi-allelic polymorphisms, the odds ratios (OR) of minor-frequency alleles compared to major alleles associated with severe and cerebral malaria were analyzed. For polymorphisms with more than 2 alleles, the presence/absence of individual alleles were compared. OR and P-values are shown, with significant differences in red bold. NA. (not applicable) indicates bi-allelic polymorphisms with a minor allele frequency <10% and individual alleles with frequencies <10% or >90%, in which their association with malaria severity were not analyzed. · · · ----23_33 del ----5 (8.2) 2 (3.6) 5 (10.9) 12 (7.4) NA. NA. NA.
a Position relative to the first aa. of each block (Fig 3). b Major haplotypes (frequency ≥ 10%) observed in the parasite population that were analyzed for association with malaria severity.
c Haplotype frequencies were compared between mild (M) and severe (S), mild and cerebral (C), as well as severe and cerebral. P-values and odds ratios (OR) are shown, with significant differences in red bold. NA. (not applicable) indicates haplotypes with frequencies >10% whose associations with malaria severity were not analyzed.