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Zhaoqing Du, Jian Dong, Jianbin Bi, Ruhai Bai, Jia Zhang, Zheng Wu, Yi Lv, Xufeng Zhang, Rongqian Wu
Predictive value of the preoperative neutrophil-to-lymphocyte ratio for the development of hepatocellular carcinoma in HBV-associated cirrhotic patients after splenectomy
www.plosone.org
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(as)Tj
1.0148 0 Td
(185)Tj
1.6497 0 Td
(months.)Tj
3.5093 0 Td
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1.7801 0 Td
(overall)Tj
2.9027 0 Td
(survival)Tj
-33.5903 -1.2983 Td
(rate)Tj
1.7461 0 Td
(was)Tj
1.7008 0 Td
(84.3%.)Tj
ET
Q
q
1 j
1 J
0 w
11.9999 0 0 11.9999 200.0125 230.0031 cm
BT
/F10 1 Tf
1 TL
-0.0033 Tc
0 0 Td
(Preoperative)Tj
5.5512 0 Td
(NLR)Tj
2.1543 0 Td
(score)Tj
2.3764 0 Td
(and)Tj
1.7953 0 Td
(HCC)Tj
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(development)Tj
ET
Q
q
1 j
1 J
0 w
10 0 0 10 200.0125 212.9952 cm
BT
/F5 1 Tf
1 TL
-0.004 Tc
0 0 Td
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3.135 0 Td
(the)Tj
1.4684 0 Td
(follow-up)Tj
4.0932 0 Td
(period,)Tj
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(38)Tj
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(\(16.52%\))Tj
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(out)Tj
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(of)Tj
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(230)Tj
1.6497 0 Td
(patients)Tj
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(with)Tj
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(HBV-related)Tj
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(cirrhosis)Tj
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(developed)Tj
4.2689 0 Td
(HCC)Tj
2.3131 0 Td
(after)Tj
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(splenectomy.)Tj
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1.7801 0 Td
(cumulative)Tj
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(HCC)Tj
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(appearance)Tj
4.7508 0 Td
(rates)Tj
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(were)Tj
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(6.09%,)Tj
2.8573 0 Td
(10.87%)Tj
-34.6618 -1.3039 Td
(and)Tj
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(17.39%)Tj
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(at)Tj
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(3,)Tj
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(5)Tj
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(and)Tj
1.7291 0 Td
(10)Tj
1.1736 0 Td
(years)Tj
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(after)Tj
2.0353 0 Td
(splenectomy,)Tj
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(respectively.)Tj
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(determine)Tj
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(the)Tj
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(value)Tj
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(of)Tj
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(the)Tj
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(NLR)Tj
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(score)Tj
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(in)Tj
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(predicting)Tj
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(hepatocarcinogenesis)Tj
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(after)Tj
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(splenectomy,)Tj
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(an)Tj
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(ROC)Tj
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(curve)Tj
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(analysis)Tj
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(was)Tj
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(performed.)Tj
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(As)Tj
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(shown)Tj
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(in)Tj
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1.0375 0 Td
(Fig)Tj
1.4797 0 Td
(1A)Tj
0 g
(,)Tj
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(the)Tj
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(preoperative)Tj
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(NLR)Tj
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(score)Tj
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(had)Tj
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(a)Tj
0.652 0 Td
(positive)Tj
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(corre-)Tj
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(lation)Tj
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(with)Tj
2.0012 0 Td
(the)Tj
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(HCC)Tj
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(appearance)Tj
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(rate)Tj
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(after)Tj
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(splenectomy.)Tj
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(The)Tj
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(area)Tj
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(under)Tj
2.6192 0 Td
(the)Tj
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(ROC)Tj
2.2507 0 Td
(curve)Tj
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(\(AUC\))Tj
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(was)Tj
1.6951 0 Td
(0.625)Tj
2.3527 0 Td
(\(95%)Tj
2.2677 0 Td
(confidence)Tj
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(interval,)Tj
3.4922 0 Td
(0.5270.723,)Tj
5.2157 0 Td
(P)Tj
0.7824 0 Td
(=)Tj
0.7994 0 Td
(0.018\).)Tj
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(The)Tj
1.7801 0 Td
(calculated)Tj
4.2066 0 Td
(cut-off)Tj
2.9027 0 Td
(for)Tj
1.3833 0 Td
(NLR)Tj
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(scores)Tj
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(to)Tj
1.0261 0 Td
(predict)Tj
3.0501 0 Td
(HCC)Tj
2.3131 0 Td
(development)Tj
5.4084 0 Td
(was)Tj
1.7008 0 Td
(2.27,)Tj
2.0976 0 Td
(with)Tj
1.9956 0 Td
(sensitivity)Tj
4.2236 0 Td
(of)Tj
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(63.9%,)Tj
2.8573 0 Td
(specificity)Tj
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(of)Tj
1.0148 0 Td
(65.3%,)Tj
-33.5733 -1.2983 Td
(and)Tj
1.7291 0 Td
(Youden)Tj
3.3845 0 Td
(index)Tj
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(of)Tj
1.0148 0 Td
(0.292.)Tj
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(According)Tj
4.4391 0 Td
(to)Tj
1.0204 0 Td
(the)Tj
1.474 0 Td
(cut-off)Tj
2.9027 0 Td
(value)Tj
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(of)Tj
1.0148 0 Td
(the)Tj
1.474 0 Td
(preoperative)Tj
5.2271 0 Td
(NLR)Tj
2.1146 0 Td
(score,)Tj
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(141)Tj
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(patients)Tj
3.3675 0 Td
(in)Tj
1.0375 0 Td
(this)Tj
1.6724 0 Td
(cohort)Tj
2.8516 0 Td
(had)Tj
1.7121 0 Td
(a)Tj
0.652 0 Td
(low)Tj
1.6611 0 Td
(NLR)Tj
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(score)Tj
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(\(NLR)Tj
/F14 1 Tf
0 Tc
()Tj
/F5 1 Tf
-0.004 Tc
(2.27,)Tj
5.1023 0 Td
(61.3%\))Tj
2.9707 0 Td
(and)Tj
1.7292 0 Td
(89)Tj
1.1735 0 Td
(patients)Tj
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(had)Tj
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(a)Tj
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(high)Tj
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(NLR)Tj
2.1146 0 Td
(score)Tj
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(\(NLR)Tj
/F13 1 Tf
0 Tc
(>)Tj
/F5 1 Tf
-0.004 Tc
(2.27,)Tj
5.1023 0 Td
(38.7%\).)Tj
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3.1975 0 Td
(Table)Tj
2.4434 0 Td
(2)Tj
0 g
0.6917 0 Td
(shows)Tj
2.6645 0 Td
(the)Tj
1.4683 0 Td
(demographic)Tj
5.5049 0 Td
(and)Tj
1.7291 0 Td
(preoperative)Tj
5.2271 0 Td
(data)Tj
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Q
q
0.45 0.36 0.35 0.01 k
1 j
1 J
0 w
199.9998 703.8893 m
575.9997 703.8893 l
575.9997 703.3893 l
199.9998 703.3893 l
f*
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422.0787 690.8893 l
421.5787 690.8893 l
421.5787 703.3893 l
f*
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199.9998 690.8893 l
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421.5787 691.3894 l
f*
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575.9994 691.3894 l
f*
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421.5787 678.3894 l
421.5787 690.8893 l
f*
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421.5787 678.8894 l
f*
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f*
422.0787 678.3894 m
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421.5787 665.8894 l
421.5787 678.3894 l
f*
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421.5787 666.3895 l
f*
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422.0787 665.8894 l
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f*
422.0787 665.8894 m
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421.5787 653.3895 l
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f*
421.5787 653.3895 m
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421.5787 653.8895 l
f*
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f*
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f*
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421.5787 641.3896 l
f*
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f*
422.0787 640.8896 m
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421.5787 628.3896 l
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f*
421.5787 628.3896 m
199.9998 628.3896 l
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f*
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f*
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f*
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f*
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f*
422.0787 615.8897 m
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f*
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f*
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f*
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199.9998 590.8898 l
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421.5787 591.3899 l
f*
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422.0787 590.8898 l
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f*
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f*
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421.5787 578.3899 l
f*
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199.9998 565.89 l
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f*
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422.0787 565.89 l
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f*
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f*
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f*
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422.0787 553.39 l
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f*
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421.5787 540.8901 l
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f*
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f*
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f*
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421.5787 528.3901 l
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f*
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f*
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f*
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f*
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f*
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f*
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f*
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f*
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f*
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f*
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f*
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f*
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f*
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f*
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f*
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350.7591 340.3276 l
h
f*
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7.9999 0 0 7.9999 200.0125 708.7181 cm
BT
/F10 1 Tf
1 TL
-0.005 Tc
0 0 Td
(Table)Tj
2.5512 0 Td
(1.)Tj
1.1763 0 Td
(Clinical)Tj
3.4512 0 Td
(characteris)Tj
4.5426 0 Td
(tic)Tj
1.2685 0 Td
(of)Tj
1.063 0 Td
(the)Tj
1.5307 0 Td
(230)Tj
1.7008 0 Td
(patients.)Tj
0 Tc
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(Patient)Tj
3.274 0 Td
(Demogr)Tj
3.4441 0 Td
(aphics)Tj
2.8985 0 Td
(and)Tj
1.8071 0 Td
(Clinical)Tj
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(Characteri)Tj
4.4646 0 Td
(stics)Tj
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(Median\(ran)Tj
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(ge\)/n\(percen)Tj
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(tage\))Tj
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(N)Tj
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(230)Tj
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(Age\(years\))Tj
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(44\(2066\))Tj
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(Gender)Tj
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(\(male:)Tj
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(female\))Tj
22.1529 0 Td
(174:56)Tj
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(Coexisti)Tj
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(ng)Tj
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(conditions)Tj
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(Drinkin)Tj
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(g)Tj
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(25\(10.87%\))Tj
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(Smoking)Tj
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(54\(23.48%\))Tj
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(Hyperte)Tj
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(nsion)Tj
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(49\(21.30%\))Tj
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(Diabetes)Tj
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(16\(6.96%)Tj
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(\))Tj
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