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Jorge López, Sarah N. Fernández, Rafael González, María J. Solana, Javier Urbano, Blanca Toledo, Jesús López-Herce
Comparison between manual and mechanical chest compressions during resuscitation in a pediatric animal model of asphyxial cardiac arrest
www.plosone.org
www.plosone.org
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1.7008 0 Td
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2.7948 0 Td
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1.0318 0 Td
(the)Tj
1.474 0 Td
(contralateral)Tj
-31.0844 -1.2983 Td
(femoral)Tj
3.3108 0 Td
(artery.)Tj
2.795 0 Td
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2.5908 0 Td
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1.4797 0 Td
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3.4809 0 Td
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1.0375 0 Td
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0.6519 0 Td
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2.3981 0 Td
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3.4526 0 Td
(300)Tj
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Q
q
1 j
1 J
0 w
7.4999 0 0 6.6659 488.8629 581.8393 cm
BT
/F12 1 Tf
1 TL
-0.0053 Tc
0 0 Td
(1)Tj
ET
Q
q
1 j
1 J
0 w
10 0 0 10 498.5574 577.4173 cm
BT
/F7 1 Tf
1 TL
-0.004 Tc
0 0 Td
(gas)Tj
1.4796 0 Td
(analyzer)Tj
-31.3339 -1.3039 Td
(\(Instrumentation)Tj
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4.8699 0 Td
(Lexington,)Tj
4.507 0 Td
(Kentuky,)Tj
3.8665 0 Td
(USA\).)Tj
-19.1961 -1.2982 Td
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2.2903 0 Td
(a)Tj
0.652 0 Td
(30-minute)Tj
4.405 0 Td
(stabilization)Tj
5.0683 0 Td
(period,)Tj
3.0614 0 Td
(baseline)Tj
3.4299 0 Td
(data)Tj
1.9162 0 Td
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1.0205 0 Td
(assess)Tj
2.5228 0 Td
(ventilation)Tj
4.5127 0 Td
(and)Tj
1.7291 0 Td
(oxygenation.)Tj
-0.02 Tc
-18.2776 -1.3039 Td
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4.0365 0 Td
(cardiac)Tj
2.9877 0 Td
(arrest)Tj
2.3867 0 Td
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3.3505 0 Td
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1.1509 0 Td
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5.6239 0 Td
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1.423 0 Td
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2.1373 0 Td
(the)Tj
1.4229 0 Td
(ventilator)Tj
3.9118 0 Td
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-33.9645 -1.2983 Td
(10)Tj
1.1396 0 Td
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3.3505 0 Td
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1.9559 0 Td
(receiving)Tj
3.7247 0 Td
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1.1679 0 Td
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4.1158 0 Td
(bolus)Tj
2.2904 0 Td
(of)Tj
0.9808 0 Td
(atracurium)Tj
4.5354 0 Td
(\(0.5)Tj
1.6724 0 Td
(mg/kg\))Tj
3.0444 0 Td
([)Tj
0.83 0.64 0.02 0 k
(18)Tj
0 g
(,)Tj
0.83 0.64 0.02 0 k
(19)Tj
0 g
(,)Tj
0.83 0.64 0.02 0 k
(20)Tj
0 g
(,)Tj
0.83 0.64 0.02 0 k
(21)Tj
0 g
(,)Tj
0.83 0.64 0.02 0 k
(22)Tj
0 g
(].)Tj
6.5082 0 Td
(Time)Tj
2.2791 0 Td
(to)Tj
-36.7651 -1.2982 Td
(cardiac)Tj
2.9877 0 Td
(arrest)Tj
2.3811 0 Td
(was)Tj
1.6555 0 Td
(registered.)Tj
4.2009 0 Td
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3.2258 0 Td
(arrest)Tj
2.3867 0 Td
(was)Tj
1.6498 0 Td
(defined)Tj
3.1124 0 Td
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0.9865 0 Td
(a)Tj
0.6349 0 Td
(mean)Tj
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(arterial)Tj
2.9424 0 Td
(pressure)Tj
3.4468 0 Td
(\(MAP\))Tj
2.9536 0 Td
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-34.9452 -1.2983 Td
(25)Tj
1.1396 0 Td
(mmHg)Tj
3.0274 0 Td
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0.9807 0 Td
(has)Tj
1.4967 0 Td
(been)Tj
2.058 0 Td
(described)Tj
3.9061 0 Td
(previously)Tj
4.1952 0 Td
([)Tj
0.83 0.64 0.02 0 k
(18)Tj
0 g
(,)Tj
0.83 0.64 0.02 0 k
(19)Tj
0 g
(,)Tj
0.83 0.64 0.02 0 k
(20)Tj
0 g
(,)Tj
0.83 0.64 0.02 0 k
(21)Tj
0 g
(,)Tj
0.83 0.64 0.02 0 k
(22)Tj
0 g
(].)Tj
6.5083 0 Td
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2.2054 0 Td
(10)Tj
1.1395 0 Td
(minutes)Tj
3.3561 0 Td
(of)Tj
0.9808 0 Td
(asphyxia)Tj
3.5546 0 Td
(all)Tj
1.0998 0 Td
(pigs)Tj
-35.6482 -1.3039 Td
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1.0034 0 Td
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2.9877 0 Td
(arrest.)Tj
2.5966 0 Td
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1.1678 0 Td
(this)Tj
1.6101 0 Td
(moment)Tj
3.5433 0 Td
(data)Tj
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3.8947 0 Td
(monitoring)Tj
4.6602 0 Td
(parameters)Tj
4.5183 0 Td
(and)Tj
1.6781 0 Td
(blood)Tj
2.4377 0 Td
(gases)Tj
-34.0041 -1.2983 Td
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2.058 0 Td
(recorded)Tj
3.668 0 Td
(and)Tj
1.6838 0 Td
(then)Tj
1.9502 0 Td
(resuscitation)Tj
5.1023 0 Td
(was)Tj
1.6498 0 Td
(started.)Tj
3.033 0 Td
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1.1679 0 Td
(this)Tj
1.6101 0 Td
(point,)Tj
2.4888 0 Td
(animals)Tj
3.2201 0 Td
(were)Tj
2.0579 0 Td
(randomized)Tj
4.8982 0 Td
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-34.5881 -1.2983 Td
(one)Tj
1.6498 0 Td
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0.9808 0 Td
(the)Tj
1.423 0 Td
(two)Tj
1.6611 0 Td
(therapeutic)Tj
4.558 0 Td
(groups:)Tj
3.0841 0 Td
(mechanical)Tj
4.6035 0 Td
(CC)Tj
1.5193 0 Td
(and)Tj
1.6781 0 Td
(manual)Tj
3.1351 0 Td
(CC)Tj
1.5137 0 Td
(with)Tj
1.9332 0 Td
(a)Tj
0.6406 0 Td
(relation)Tj
3.1861 0 Td
(of)Tj
0.9864 0 Td
(1)Tj
0.6803 0 Td
(to)Tj
0.9921 0 Td
(1.5)Tj
-34.2252 -1.3039 Td
(respectively.)Tj
4.904 0 Td
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1.8141 0 Td
(hypothesis)Tj
4.3087 0 Td
(was)Tj
1.6497 0 Td
(that)Tj
1.7121 0 Td
(mechanical)Tj
4.6091 0 Td
(device)Tj
2.6419 0 Td
(produces)Tj
3.753 0 Td
(better)Tj
2.4492 0 Td
(chest)Tj
2.1712 0 Td
(compression)Tj
5.1533 0 Td
(and)Tj
-35.1663 -1.2982 Td
(higher)Tj
2.6986 0 Td
(return)Tj
2.6589 0 Td
(of)Tj
0.9751 0 Td
(spontaneous)Tj
5.0683 0 Td
(circulation)Tj
4.354 0 Td
(\(ROSC\).)Tj
3.5149 0 Td
(So)Tj
1.1622 0 Td
(we)Tj
1.287 0 Td
(designed)Tj
3.6283 0 Td
(a)Tj
0.6349 0 Td
(randomization)Tj
5.947 0 Td
(with)Tj
1.9275 0 Td
(less)Tj
1.5421 0 Td
(num-)Tj
-35.3988 -1.2983 Td
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1.4741 0 Td
(of)Tj
0.9807 0 Td
(animals)Tj
3.2202 0 Td
(in)Tj
1.0034 0 Td
(the)Tj
1.423 0 Td
(mechanical)Tj
4.6035 0 Td
(chest)Tj
2.1769 0 Td
(compression)Tj
5.1477 0 Td
(group)Tj
2.5285 0 Td
(to)Tj
0.9978 0 Td
(try)Tj
1.2926 0 Td
(to)Tj
0.9978 0 Td
(reduce)Tj
2.8176 0 Td
(the)Tj
1.4229 0 Td
(number)Tj
3.3222 0 Td
(of)Tj
0.9808 0 Td
(animals)Tj
-34.3897 -1.3039 Td
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1.9956 0 Td
(in)Tj
1.0035 0 Td
(the)Tj
1.423 0 Td
(study.)Tj
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2.4775 0 Td
(advanced)Tj
3.8664 0 Td
(resuscitation)Tj
5.0967 0 Td
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1.6554 0 Td
(initiated:)Tj
3.617 0 Td
(the)Tj
1.4173 0 Td
(animal)Tj
2.8743 0 Td
(was)Tj
1.6554 0 Td
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4.1952 0 Td
(to)Tj
0.9978 0 Td
(the)Tj
-34.7922 -1.2983 Td
(ventilator)Tj
3.9062 0 Td
(\(with)Tj
2.262 0 Td
(the)Tj
1.4173 0 Td
(same)Tj
2.194 0 Td
(parameters)Tj
4.5184 0 Td
(as)Tj
0.9808 0 Td
(before)Tj
2.6419 0 Td
(the)Tj
1.423 0 Td
(disconnection,)Tj
5.8733 0 Td
(except)Tj
2.6759 0 Td
(for)Tj
1.3379 0 Td
(a)Tj
0.6349 0 Td
(FiO)Tj
ET
Q
q
1 j
1 J
0 w
7.4999 0 0 6.6659 513.6377 380.7496 cm
BT
/F7 1 Tf
1 TL
-0.0266 Tc
0 0 Td
(2)Tj
ET
Q
q
1 j
1 J
0 w
10 0 0 10 519.2503 382.3937 cm
BT
/F7 1 Tf
1 TL
-0.02 Tc
0 0 Td
(of)Tj
0.9807 0 Td
(1.0\).)Tj
-0.004 Tc
-31.708 -1.2982 Td
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1.1112 0 Td
(both)Tj
2.0579 0 Td
(groups)Tj
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(continuous)Tj
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2.2507 0 Td
(compression)Tj
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3.2995 0 Td
(chest)Tj
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(compressions)Tj
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2.9593 0 Td
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1.1849 0 Td
(a)Tj
0.652 0 Td
(metronome-tailored)Tj
8.3621 0 Td
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1.0148 0 Td
(100)Tj
1.6498 0 Td
(compressions)Tj
5.6863 0 Td
(per)Tj
1.5307 0 Td
(minute)Tj
3.1067 0 Td
(\(cpm\).)Tj
2.8856 0 Td
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1.61 0 Td
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2.109 0 Td
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-36.6176 -1.3039 Td
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4.0025 0 Td
(about)Tj
2.4944 0 Td
(1/3)Tj
1.5024 0 Td
(of)Tj
1.0148 0 Td
(the)Tj
1.4683 0 Td
(antero-posterior)Tj
6.7748 0 Td
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2.2563 0 Td
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4.0082 0 Td
(but)Tj
1.5534 0 Td
(depth)Tj
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2.2507 0 Td
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1.6951 0 Td
(not)Tj
1.576 0 Td
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4.337 0 Td
(A)Tj
0.9014 0 Td
(mechanical)Tj
4.7679 0 Td
(device,)Tj
2.965 0 Td
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4.0195 0 Td
(mechanical)Tj
4.7678 0 Td
(CPR,)Tj
2.2904 0 Td
(model)Tj
2.7439 0 Td
(1007/CC)Tj
3.7757 0 Td
(specially)Tj
-33.8397 -1.2982 Td
(adapted)Tj
3.3788 0 Td
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1.389 0 Td
(pediatric)Tj
3.7474 0 Td
(size)Tj
1.6894 0 Td
(\(Michigan)Tj
4.3824 0 Td
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5.3461 0 Td
(USA\))Tj
2.4548 0 Td
(was)Tj
1.7007 0 Td
(used.)Tj
2.2847 0 Td
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1.9843 0 Td
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0.8504 0 Td
(a)Tj
0.6519 0 Td
(piston)Tj
2.7212 0 Td
(mechanical)Tj
-32.5811 -1.3039 Td
(chest)Tj
2.2507 0 Td
(compression)Tj
5.3291 0 Td
(device)Tj
2.7382 0 Td
(that)Tj
1.7802 0 Td
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2.6985 0 Td
(adjustment)Tj
4.7168 0 Td
(of)Tj
1.0148 0 Td
(compression)Tj
5.3235 0 Td
(depth)Tj
2.5171 0 Td
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2.2054 0 Td
(0)Tj
0.6973 0 Td
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1.0204 0 Td
(8)Tj
0.6973 0 Td
(cm)Tj
1.4626 0 Td
(and)Tj
-34.4519 -1.2983 Td
(compression)Tj
5.3234 0 Td
(rate.)Tj
1.9729 0 Td
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2.2394 0 Td
(cycle)Tj
2.1883 0 Td
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0.8504 0 Td
(preset)Tj
2.6135 0 Td
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1.389 0 Td
(50/50)Tj
2.4491 0 Td
(cycle)Tj
2.194 0 Td
(\(50%)Tj
2.2677 0 Td
(compression)Tj
5.3291 0 Td
(and)Tj
1.7291 0 Td
(50%)Tj
1.9275 0 Td
(release\).)Tj
-32.4734 -1.2983 Td
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4.8415 0 Td
(chest)Tj
2.2507 0 Td
(compression)Tj
5.3291 0 Td
(was)Tj
1.6951 0 Td
(programmed)Tj
5.4822 0 Td
(to)Tj
1.0205 0 Td
(a)Tj
0.6576 0 Td
(rate)Tj
1.7461 0 Td
(of)Tj
1.0148 0 Td
(100)Tj
1.6441 0 Td
(cpm.)Tj
2.2053 0 Td
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5.5671 0 Td
(depth)Tj
2.5172 0 Td
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-35.9713 -1.3039 Td
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3.5773 0 Td
(before)Tj
2.7382 0 Td
(cardiac)Tj
3.1011 0 Td
(arrest)Tj
2.4775 0 Td
(in)Tj
1.0374 0 Td
(each)Tj
2.0296 0 Td
(animal)Tj
2.9707 0 Td
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1.0205 0 Td
(achieve)Tj
3.1748 0 Td
(1/3)Tj
1.5023 0 Td
(of)Tj
1.0148 0 Td
(the)Tj
1.4684 0 Td
(anteroposterior)Tj
6.4288 0 Td
(diameter)Tj
3.7871 0 Td
(of)Tj
-36.3285 -1.2983 Td
(the)Tj
1.4683 0 Td
(chest.)Tj
2.4775 0 Td
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1.7858 0 Td
(same)Tj
2.2564 0 Td
(depth)Tj
2.5171 0 Td
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1.6951 0 Td
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4.7905 0 Td
(throughout)Tj
4.7792 0 Td
(the)Tj
1.4684 0 Td
(experiment.)Tj
-22.0421 -1.2982 Td
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2.3414 0 Td
(and)Tj
1.7291 0 Td
(ECG)Tj
2.1657 0 Td
(were)Tj
2.1259 0 Td
(assessed)Tj
3.4696 0 Td
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0.9525 0 Td
(3)Tj
0.6973 0 Td
(minute)Tj
3.1067 0 Td
(intervals,)Tj
3.8495 0 Td
(during)Tj
2.9253 0 Td
(less)Tj
1.6101 0 Td
(than)Tj
2.0295 0 Td
(10)Tj
1.1736 0 Td
(seconds,)Tj
3.5942 0 Td
(and)Tj
1.7348 0 Td
(the)Tj
-34.7014 -1.3039 Td
(provider)Tj
3.6566 0 Td
(delivering)Tj
4.218 0 Td
(chest)Tj
2.2507 0 Td
(compressions)Tj
5.6919 0 Td
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1.6951 0 Td
(swapped)Tj
3.685 0 Td
(to)Tj
1.0262 0 Td
(avoid)Tj
2.4094 0 Td
(fatigue.)Tj
3.1521 0 Td
(Adrenaline)Tj
4.694 0 Td
(\(0.02)Tj
2.211 0 Td
(mg/)Tj
-34.69 -1.2983 Td
(kg/dose\))Tj
3.668 0 Td
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1.7008 0 Td
(administered)Tj
5.4878 0 Td
(every)Tj
2.3471 0 Td
(3)Tj
0.6973 0 Td
(minutes)Tj
3.4639 0 Td
(and)Tj
1.7348 0 Td
(sodium)Tj
3.2258 0 Td
(bicarbonate)Tj
4.9436 0 Td
(\(1)Tj
1.0375 0 Td
(mEq/kg/dose\))Tj
5.8959 0 Td
(at)Tj
0.9524 0 Td
(9)Tj
0.6917 0 Td
(and)Tj
-35.8466 -1.2983 Td
(18)Tj
1.1678 0 Td
(minutes)Tj
3.4696 0 Td
(of)Tj
1.0148 0 Td
(CPR.)Tj
2.2904 0 Td
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3.5773 0 Td
(were)Tj
2.126 0 Td
(defibrillated)Tj
5.0456 0 Td
(\(4)Tj
1.0375 0 Td
(J/Kg\))Tj
2.3584 0 Td
(if)Tj
0.771 0 Td
(a)Tj
0.6576 0 Td
(shockable)Tj
4.1443 0 Td
(rhythm)Tj
3.2201 0 Td
(was)Tj
1.695 0 Td
(identified;)Tj
-32.5754 -1.2982 Td
(adrenaline)Tj
4.4447 0 Td
(and)Tj
1.7291 0 Td
(amiodarone)Tj
5.057 0 Td
(\(5)Tj
1.0374 0 Td
(mg/kg\))Tj
3.1351 0 Td
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2.126 0 Td
(administered)Tj
5.4878 0 Td
(after)Tj
2.0353 0 Td
(the)Tj
1.4683 0 Td
(third)Tj
2.2111 0 Td
(defibrillation.)Tj
-27.5356 -1.3039 Td
(The)Tj
1.7858 0 Td
(following)Tj
3.9798 0 Td
(parameters)Tj
4.6715 0 Td
(were)Tj
2.126 0 Td
(continuously)Tj
5.4368 0 Td
(monitored)Tj
4.49 0 Td
(and)Tj
1.7291 0 Td
(collected)Tj
3.7361 0 Td
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0.9524 0 Td
(baseline)Tj
3.4355 0 Td
(and)Tj
1.7291 0 Td
(every)Tj
-35.2683 -1.2983 Td
(3)Tj
0.6916 0 Td
(minutes)Tj
3.4696 0 Td
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2.0353 0 Td
(the)Tj
1.4683 0 Td
(initiation)Tj
3.9231 0 Td
(of)Tj
1.0148 0 Td
(CPR:)Tj
2.2904 0 Td
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2.5115 0 Td
(rate)Tj
1.7518 0 Td
(and)Tj
1.7291 0 Td
(rhythm,)Tj
3.4412 0 Td
(systolic)Tj
3.1408 0 Td
(arterial)Tj
3.0671 0 Td
(pressure)Tj
3.5772 0 Td
(\(SAP\),)Tj
-34.1118 -1.2983 Td
(diastolic)Tj
3.5489 0 Td
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