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Jean A. Hall, Maha Yerramilli, Edward Obare, Jun Li, Murthy Yerramilli, Dennis E. Jewell
Serum concentrations of symmetric dimethylarginine and creatinine in cats with kidney stones
www.plosone.org
www.plosone.org
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1.7347 0 Td
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1.4287 0 Td
(cats)Tj
1.7405 0 Td
(diagnosed)Tj
4.2802 0 Td
(antemortem)Tj
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(alive;)Tj
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(six)Tj
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(deceased.)Tj
3.9912 0 Td
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(three)Tj
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4.4674 0 Td
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1.474 0 Td
(Minnesota)Tj
4.4957 0 Td
(Urolith)Tj
3.1748 0 Td
(Center)Tj
2.948 0 Td
(\(University)Tj
4.7452 0 Td
(of)Tj
1.0148 0 Td
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-31.9689 -1.3039 Td
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(Paul,)Tj
2.211 0 Td
(MN\))Tj
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1.0375 0 Td
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1.7347 0 Td
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2.0013 0 Td
(stones)Tj
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(34\).)Tj
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3.3618 0 Td
(oxalate)Tj
3.0274 0 Td
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0.805 0 Td
(30;)Tj
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(5)Tj
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1.7064 0 Td
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3.515 0 Td
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(100%)Tj
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0 Tc
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1.3323 0 Td
(14)Tj
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1.1679 0 Td
[()]TJ
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(g/dL\))Tj
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2.3301 0 Td
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1.0204 0 Td
(death)Tj
2.4321 0 Td
(in)Tj
1.0375 0 Td
(39)Tj
1.1735 0 Td
(of)Tj
1.0148 0 Td
(43)Tj
1.1679 0 Td
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-35.6596 -1.2983 Td
(kidney)Tj
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(stones.)Tj
2.9424 0 Td
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1.1111 0 Td
(4)Tj
0.6974 0 Td
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1.9615 0 Td
(all)Tj
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0 Tc
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-0.004 Tc
1.3322 0 Td
(14)Tj
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1.1736 0 Td
[()]TJ
/F7 1 Tf
(g/dL\).)Tj
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(diagnosis)Tj
3.9571 0 Td
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2.9367 0 Td
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2.7212 0 Td
(antemortem)Tj
5.1647 0 Td
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3.4866 0 Td
(or)Tj
1.0998 0 Td
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1.4684 0 Td
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(postmortem)Tj
5.1477 0 Td
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0.9524 0 Td
(necropsy)Tj
3.8268 0 Td
(as)Tj
1.0148 0 Td
(the)Tj
1.4683 0 Td
(gold)Tj
1.9673 0 Td
(standard,)Tj
3.9458 0 Td
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4.2236 0 Td
(\(91%\),)Tj
2.8346 0 Td
(specificity)Tj
4.2066 0 Td
(\(100%\),)Tj
3.3108 0 Td
(PPV)Tj
-35.6142 -1.2982 Td
(\(100%\),)Tj
3.3108 0 Td
(and)Tj
1.7291 0 Td
(NPV)Tj
2.211 0 Td
(\(84%\))Tj
2.6079 0 Td
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2.1203 0 Td
(calculated)Tj
4.2066 0 Td
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1.3833 0 Td
(serum)Tj
2.7269 0 Td
(SDMA)Tj
3.0047 0 Td
(concentration.)Tj
6.0434 0 Td
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2.8403 0 Td
(Cr)Tj
1.2529 0 Td
(was)Tj
-33.4372 -1.2983 Td
(increased)Tj
3.9968 0 Td
(at)Tj
0.9524 0 Td
(some)Tj
2.3357 0 Td
(point)Tj
2.3528 0 Td
(prior)Tj
2.2563 0 Td
(to)Tj
1.0262 0 Td
(death)Tj
2.4321 0 Td
(in)Tj
1.0318 0 Td
(18)Tj
1.1735 0 Td
(of)Tj
1.0148 0 Td
(43)Tj
1.1736 0 Td
(cats;)Tj
1.9615 0 Td
(6)Tj
0.6917 0 Td
(of)Tj
1.0148 0 Td
(the)Tj
1.474 0 Td
(18)Tj
1.1678 0 Td
(cats)Tj
1.7405 0 Td
(had)Tj
1.7065 0 Td
(terminal)Tj
3.6283 0 Td
(azotemia)Tj
-33.1311 -1.2983 Td
(only.)Tj
2.1996 0 Td
(The)Tj
1.7858 0 Td
(mean)Tj
2.4435 0 Td
(time)Tj
2.0296 0 Td
(that)Tj
1.7745 0 Td
(serum)Tj
2.7269 0 Td
(SDMA)Tj
3.0103 0 Td
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1.6952 0 Td
(increased)Tj
4.0024 0 Td
(before)Tj
2.7383 0 Td
(serum)Tj
2.7212 0 Td
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1.2586 0 Td
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1.6951 0 Td
(increased)Tj
4.0025 0 Td
(in)Tj
1.0375 0 Td
(these)Tj
-35.121 -1.3039 Td
(39)Tj
1.1678 0 Td
(cats)Tj
1.7405 0 Td
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1.6951 0 Td
(26.9)Tj
1.8765 0 Td
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3.2825 0 Td
(\(range,)Tj
3.0274 0 Td
(0)Tj
0.6916 0 Td
(to)Tj
1.0262 0 Td
(60.0)Tj
1.8765 0 Td
(months\).)Tj
3.8438 0 Td
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2.8403 0 Td
(urea)Tj
1.9729 0 Td
(nitrogen)Tj
3.651 0 Td
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1.7007 0 Td
(increased)Tj
3.9969 0 Td
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0.9524 0 Td
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(point)Tj
2.3584 0 Td
(prior)Tj
2.2507 0 Td
(to)Tj
1.0261 0 Td
(death)Tj
2.4321 0 Td
(in)Tj
1.0375 0 Td
(25)Tj
1.1678 0 Td
(of)Tj
1.0148 0 Td
(43)Tj
1.1736 0 Td
(cats;)Tj
1.9615 0 Td
(10)Tj
1.1736 0 Td
(of)Tj
1.0148 0 Td
(the)Tj
1.4683 0 Td
(25)Tj
1.1679 0 Td
(cats)Tj
1.7404 0 Td
(had)Tj
1.7065 0 Td
(terminal)Tj
3.6283 0 Td
(elevation)Tj
3.8268 0 Td
(only.)Tj
-28.9529 -1.2983 Td
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2.5681 0 Td
(specific)Tj
3.1918 0 Td
(gravity)Tj
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0 Tc
1.7008 0 Td
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-0.004 Tc
0.9921 0 Td
(1.035)Tj
2.3471 0 Td
(in)Tj
1.0375 0 Td
(15)Tj
1.1679 0 Td
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(39)Tj
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(and)Tj
1.7291 0 Td
(UPC)Tj
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0 Tc
1.6951 0 Td
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0.9921 0 Td
(0.4)Tj
1.3947 0 Td
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1.0374 0 Td
(6)Tj
0.6973 0 Td
(of)Tj
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(27)Tj
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1.9955 0 Td
(kidney)Tj
2.9367 0 Td
(stones)Tj
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(at)Tj
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(the)Tj
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(time)Tj
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(if)Tj
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(that)Tj
1.7802 0 Td
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(kidney)Tj
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(37\))Tj
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(12.5)Tj
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(6.1)Tj
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(18.1)Tj
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(0.44)Tj
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(years\).)Tj
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(six)Tj
1.3153 0 Td
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(kidney)Tj
2.9367 0 Td
(stones)Tj
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(that)Tj
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(21\))Tj
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[()]TJ
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0 Tc
1.1055 0 Td
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-0.004 Tc
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-33.8341 -1.2982 Td
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(15.2)Tj
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2.2677 0 Td
(\(range,)Tj
3.0274 0 Td
(13.0)Tj
1.8709 0 Td
(to)Tj
1.0261 0 Td
(17.2)Tj
1.8709 0 Td
(years;)Tj
2.4888 0 Td
(SEM)Tj
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(0.58)Tj
1.8709 0 Td
(years\).)Tj
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0.6973 0 Td
(healthy)Tj
3.1351 0 Td
(control)Tj
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(cats)Tj
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1.6384 0 Td
(alive;)Tj
2.2677 0 Td
(these)Tj
2.2563 0 Td
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1.7348 0 Td
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2.126 0 Td
(included)Tj
3.7134 0 Td
(using)Tj
2.3867 0 Td
(their)Tj
2.109 0 Td
(current)Tj
3.1861 0 Td
(age)Tj
1.542 0 Td
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1.0148 0 Td
(age)Tj
1.5421 0 Td
(of)Tj
1.0148 0 Td
(death.)Tj
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Q
q
1 j
1 J
0 w
11.9999 0 0 11.9999 200.0125 217.0204 cm
BT
/F0 1 Tf
1 TL
-0.0033 Tc
0 0 Td
(Cats)Tj
2.2535 0 Td
(with)Tj
1.9796 0 Td
(kidney)Tj
3.0708 0 Td
(stones)Tj
3.1371 0 Td
(diagnosed)Tj
4.7669 0 Td
(antemortem)Tj
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Q
q
1 j
1 J
0 w
10 0 0 10 200.0125 200.0125 cm
BT
/F7 1 Tf
1 TL
-0.004 Tc
0 0 Td
(The)Tj
1.7801 0 Td
(12)Tj
1.1735 0 Td
(cats)Tj
1.7348 0 Td
(diagnosed)Tj
4.2803 0 Td
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2.0013 0 Td
(kidney)Tj
2.9366 0 Td
(stones)Tj
2.7213 0 Td
(antemortem)Tj
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(by)Tj
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(radiographic)Tj
5.3347 0 Td
(imaging)Tj
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1.3833 0 Td
(sev-)Tj
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1.6951 0 Td
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(21.5)Tj
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(range)Tj
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(5.047.0)Tj
3.566 0 Td
(months\).)Tj
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(data,)Tj
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(\(median;)Tj
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(summarized)Tj
5.1874 0 Td
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1.0375 0 Td
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2.4377 0 Td
(1)Tj
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(SDMA,)Tj
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(Cr,)Tj
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(urea)Tj
1.9729 0 Td
(nitrogen)Tj
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1.3833 0 Td
(USC)Tj
2.0977 0 Td
(and)Tj
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(UPC)Tj
2.177 0 Td
(ratios,)Tj
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(both)Tj
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(the)Tj
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(diagnosis)Tj
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(the)Tj
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(time)Tj
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1.0941 0 Td
(last)Tj
1.5591 0 Td
(assessment)Tj
4.6147 0 Td
(if)Tj
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(still)Tj
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(alive.)Tj
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1.2018 0 Td
(the)Tj
1.4684 0 Td
(time)Tj
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(of)Tj
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(diagnosis,)Tj
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(serum)Tj
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(SDMA)Tj
3.0047 0 Td
(concentrations)Tj
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(increased)Tj
4.0024 0 Td
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(92%)Tj
1.9332 0 Td
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(these)Tj
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1.7404 0 Td
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(Fig)Tj
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(1)Tj
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(\),)Tj
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(serum)Tj
2.7213 0 Td
(urea)Tj
1.9785 0 Td
(nitrogen)Tj
3.651 0 Td
(in)Tj
1.0318 0 Td
(25%)Tj
1.9333 0 Td
(of)Tj
1.0148 0 Td
(cats,)Tj
1.9615 0 Td
(and)Tj
1.7291 0 Td
(serum)Tj
2.7213 0 Td
(Cr)Tj
-35.9147 -1.2982 Td
(in)Tj
1.0318 0 Td
(17%)Tj
1.9332 0 Td
(of)Tj
1.0148 0 Td
(cats)Tj
1.7348 0 Td
(\()Tj
0.83 0.64 0.02 0 k
(Fig)Tj
1.8198 0 Td
(2)Tj
0 g
(\).)Tj
1.2586 0 Td
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1.7858 0 Td
(USG)Tj
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1.6951 0 Td
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(1.035)Tj
2.347 0 Td
(in)Tj
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(10)Tj
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(out)Tj
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