Association between Obesity and Cardiometabolic Health Risk in Asian-Canadian Sub-Groups

Objectives To quantify and compare the association between the World Health Organizations’ Asian-specific trigger points for public health action [‘increased risk’: body mass index (BMI) ≥23 kg/m2, and; ‘high risk’: BMI ≥27.5 kg/m2] with self-reported cardiovascular-related conditions in Asian-Canadian sub-groups. Methods Six cycles of the Canadian Community Health Survey (2001–2009) were pooled to examine BMI and health in Asian sub-groups (South Asians, Chinese, Filipino, Southeast Asians, Arabs, West Asians, Japanese and Korean; N = 18 794 participants, ages 18–64 y). Multivariable logistic regression, adjusting for demographic, lifestyle characteristics and acculturation measures, was used to estimate the odds of cardiovascular-related health (high blood pressure, heart disease, diabetes, ‘at least one cardiometabolic condition’) outcomes across all eight Asian sub-groups. Results Compared to South Asians (OR = 1.00), Filipinos had higher odds of having ‘at least one cardiometabolic condition’ (OR = 1.29, 95% CI: 1.04–1.62), whereas Chinese (0.63, 0.474–0.9) and Arab-Canadians had lower odds (0.38, 0.28–0.51). In ethnic-specific analyses (with ‘acceptable’ risk weight as the referent), ‘increased’ and ‘high’ risk weight categories were the most highly associated with ‘at least one cardiometabolic condition’ in Chinese (‘increased’: 3.6, 2.34–5.63; ‘high’: 8.9, 3.6–22.01). Compared to normal weight South Asians, being in the ‘high’ risk weight category in all but the Southeast Asian, Arab, and Japanese ethnic groups was associated with approximately 3-times the likelihood of having ‘at least one cardiometabolic condition’. Conclusion Differences in the association between obesity and cardiometabolic health risks were seen among Asian sub-groups in Canada. The use of WHO’s lowered Asian-specific BMI cut-offs identified obesity-related risks in South Asian, Filipino and Chinese sub-groups that would have been masked by traditional BMI categories. These findings have implications for public health messaging, especially for ethnic groups at higher odds of obesity-related health risks.


Introduction
Asians currently represent the fastest growing ethnic group in Canada, with South Asians (4.0% of total Canadian population) and Chinese (3.9%) currently ranked as the first and second largest visible minority groups, respectively [1]. Statistics Canada has projected that by 2031, the visible minority population in Canada could increase to 14.4 million people, more than double the 5.3 million reported in 2006 [2]. The largest contributors to this increase are the South Asian population, which is expected to increase 3-fold from 1.3 million in 2006 to 4.1 million in 2031, while the Chinese population is projected to grow from 1.3 million to 3 million [2].
Our knowledge of obesity and cardiometabolic health risks has been historically derived from studies of Occidental groups or persons of White European or American ancestry, the assumptions of which may not hold true when applied to other ethnic groups [3,4]. Despite having a lower prevalence of obesity, Asians are known to be at an increased risk of cardiovascular disease (CVD) risk factors compared with those of European descent [4][5][6][7][8][9], a finding that has been attributed at least in part due to differences in body fat distribution and body build and frame size [10][11][12][13][14]. Moreover, CVD risk factors associated with excess weight also vary by Asian sub-groups [4,7,[15][16][17][18][19][20]. For example, despite lower mean body mass index (BMI), Asian Americans are 30-50% more likely to have Type 2 Diabetes Mellitus (T2DM) than their White counterparts (6). In this analysis, Asian Indians had the highest odds of prevalent type 2 diabetes, followed by Filipinos, other Asians, and Chinese [6]. Insulin resistance has also shown to be higher in Asian Indians, and higher prevalence of metabolic syndrome is seen among Filipino and Japanese compared to other Asian groups [8,[21][22][23].
Given that health risk associated with a given level of adiposity has been shown to be higher in Asians when compared with White Europeans and Americans, the use of conventional BMI cut-off points of 25 kg/m 2 (overweight) and 30 kg/m 2 (obesity) may underestimate the prevalence of obesity and its associated health risk [3,9,11]. In light of this, the World Health Organization (WHO) in 2004 created Asian-specific BMI trigger points for public health action. BMI cut-off points traditionally used for overweight and obesity ($25 kg/m 2 and $30 kg/m 2 , respectively) were lowered to $23 kg/m 2 and $27.5 kg/m 2 to represent 'increased risk' and 'high-risk' categories, respectively [24].
In order to improve public health screening and to develop ethnic-specific CVD prevention strategies in diverse communities, the relationship of obesity to cardiometabolic risk factors requires additional study. Therefore, the objective of this analysis is to compare the association between the World Health Organization's Asian-specific BMI trigger points with self-reported cardiometabolic health amongst Asian-Canadian sub-groups.

Data source
This population-based analysis is based on data from six cycles of the Canadian Community Health Survey (CCHS; Cycles 1.1, 2.1, 3.1, 2007, 2008, and 2009), obtained through the limited data access program at the York University chapter of the Toronto Research Data Center of Statistics Canada.
The CCHS is a national cross-sectional survey that collects information related to health status, health care utilization and health determinants for the Canadian population [25]. It relies upon a large sample of respondents and is designed to provide reliable estimates at the health region level. Data collection occurred every two years prior to 2007 (i.e. Interviews were conducted both in person and over the telephone. Three sampling frames were used to select the sample of households: 49% of the sample of households came from an area frame, 50% came from a list frame of telephone numbers and the remaining 1% came from a Random Digit Dialing (RDD) sampling frame.
The CCHS targets persons aged 12 years or older who are living in private dwellings in the ten provinces and the three territories. Excluded from this survey are persons living on aboriginal settlements, reserves, or crown lands, residents of institutions, full-time members of the Canadian Armed Forces and residents of certain remote regions. Its coverage is in the range of 98% in the provinces, but varies across other regions (Territories: 98%; Yukon: ,90%; Northwest Territories: 97%, and; Nunavut: 71% (due to the exclusion of some remote regions)). To provide reliable estimates, a sample of 65 000 respondents is required on an annual basis for a total of approximately 130 000 respondents per every 2-year cycle.
Consistent with previous studies [18,26,27], the six survey cycles were pooled to obtain a sufficient sample size for the exploration of sub-group differences [28,29].

Study variables
Independent (exposure) variables. All participants were asked to self-ascribe which cultural and racial background they were from. To assess Asian ancestry, only participants who selfascribed an ethnicity as Chinese, South Asian (e.g., East Indian, Pakistani, Sri Lankan), Filipino, Southeast Asian (e.g., Cambodian, Indonesian, Laotian, Vietnamese), Arab, West Asian (e.g., Afghan, Iranian), Japanese, and Korean were retained for further analysis. The classification of Arabs as an Asian subgroup has been used in previous studies [18,27,31,32]. Self-reported height without shoes (in metres) and weight (in kilograms) was used to place respondent's into the WHO's Asian specific trigger points for public health action representing 'increased risk' (BMI $23 kg/ m 2 ) and 'high risk' (BMI $27.5 kg/m 2 ) [24].
Dependent (outcome) variables. Participants were asked about ''long-term conditions'' which were expected to last (or had already lasted) 6 months or more and that had been diagnosed by a health professional. Obesity-related cardiovascular conditions in the current analysis included self-reported high blood pressure (yes/no), diabetes (yes/no), heart disease (yes/no), and a composite variable of the presence of 'at least one cardiometabolic condition' (i.e. the presence of either high blood pressure, diabetes or heart disease).
Covariates. Demographic characteristics included sex, age of participant at time of survey, marital status (single/never married vs. other), highest level of education attained (less than secondary school graduation, secondary school graduation, some postsecondary, post-secondary graduation), household income, urban versus rural dwelling, immigrant status (non-immigrant vs. immigrant), length of time since immigration (years), and ability to 'converse in English' (yes/no). Income adequacy (i.e., lowest, lower-middle, upper-middle and highest income) was subsequently estimated using annual household income and household size as defined by Statistics Canada [33,34].
Lifestyle characteristics included sedentary leisure time, leisure time physical activity, daily fruit and vegetable consumption, stress level, smoking status (''never smoked'' vs ''ever smoked'') and alcohol consumption (''did not drink in the last 12 months'', ''occasional drinker'', and ''regular drinker''). Sedentary leisure time (defined as the total number of hours per week respondents spent reading, watching television or videos, playing video games and on the computer) was categorized into 3 groups by tertiles (# 14 hrs/week, 15-24 hrs/week, and $25 hrs/week). A leisure time physical activity index (PAI; kcal/kg/day; kkd) was created; this variable reflects the average daily energy expenditure of leisure time activities in the past three months and is based on selfreported frequency and duration of physical activity along with the metabolic equivalent of each activity. Daily consumption of fruits and vegetables was quantified as the number of times (frequency) per day, rather than the amount consumed. Participants were asked to rate their self-perceived life stress on most days (''not at all stressful'', ''not very stressful'', ''a bit stressful'', ''quite a bit stressful'', and ''extremely stressful'').

Statistical analysis
The combination of data from different cycles required a recalculation of sample weights to represent the characteristics of the pooled sample, which covers the combined time periods of the individual cycles. The original sampling weights were rescaled by a Obesity and Cardiometabolic Health Risk in Asian-Canadian Sub-Groups Three logistic regression models were subsequently used to explore the independent and joint effects of ethnicity and overweight/obesity on cardiometabolic-related health. First, the odds of obesity-related chronic disease in Asian sub-groups (compared to South Asians; OR = 1.00) was estimated after accounting for various demographic, lifestyle, and acculturation characteristics. Second, logistic regression was used to estimate the odds of cardiometabolic diseases by BMI categories (compared to the 'acceptable risk' BMI category ($18.5-23 kg/m 2 ; OR = 1.00)) within each ethnic group. Finally, an overall analysis using South Asians in the 'acceptable risk' category as the referent group was conducted to examine the effect of obesity on chronic conditions across all BMI and Asian ethnic groups concurrently. Consistent with Statistics Canada guidelines, all cells with less than 10 observations, or a coefficient of variation $33% were suppressed [29]. All analyses were conducted using SAS version 9.2 (Cary, NC, U.S.A) with statistical significance was set at an alpha of 0.05.

Descriptive characteristics
Characteristics of participants are presented in Table 1. The mean age of the pooled sample was 38.7 years, and 52.8% were male. Of the eight Asian ethnic groups, Chinese and South Asians accounted for the majority of the study sample (approximately 31% each), while Japanese accounted for the fewest (1.6%). The mean BMI overall was 24 kg . m 22 , with a distribution of 43.4%, 41.5% and 15.1% in the 'acceptable risk', 'increased risk' and 'high risk' categories, respectively, based on WHO's Asian-specific BMI trigger points. Eighty-five percent of the sample identified themselves as immigrants to Canada. Furthermore, the majority of respondents had a household education level of at least college or university, and belonged to the 'Upper Middle' or the 'Highest' income quartiles. . While Japanese and Koreans were most likely to report having ever smoked cigarettes (50.8% and 49.8%, respectively) and being regular drinkers of alcohol (60.7% and 58.5%, respectively), they were also most likely to be classified as physically active (23% and 26.7%, respectively).
Mean BMI over the 6 CCHS cycles (9 year period) has increased significantly for each Asian ethnicity except Filipino, Japanese and Korean. This trend was strongest in Southeast Asians and Chinese ( Figure 1). There was no significant difference in mean BMI for Filipinos from 2001 to 2009 (p trend = 0.18), whereas mean BMI decreased in Japanese and Korean subgroups (p trend ,0.05). Figure 2 presents the prevalence of self-reported cardiovascular conditions according to ethnicity. In general, Filipinos were most likely to report having high blood pressure (15.4%) and 'at least one cardiometabolic condition' (18.4%), whereas South Asians (6.2%) and West Asians (6.0%) were most likely to report having diabetes. West Asians also reported the highest prevalence of heart disease (6.5%).

Association between ethnicity and cardiometabolic conditions
The odds of reporting a physician-diagnosed cardiometabolic condition (i.e. high blood pressure, diabetes, heart disease, or 'at least one cardiometabolic condition') for each ethnic group compared to South Asians (OR = 1.00) is presented in Table 3. After adjusting for covariates, when compared to South Asians, Filipinos reported a 60% greater likelihood of high blood pressure (OR, lower CI-upper CI) (1.6, 1.05-2.44). As expected, nearly all Asian sub-groups had lower odds of diabetes compared to South Asians. Compared to South Asians, the odd of having 'at least one cardiometabolic condition' was significantly lower in Chinese (0.63, 0.44-0.90) and Arabs (0.38, 0.28-0.51), but significantly higher in Filipinos (1.29, 1.04-1.62); no differences were observed in the other Asian ethnic groups. Association between ethnicity, BMI category and 'at least one cardiometabolic condition' Table 4 shows the adjusted odds of 'at least one cardiometabolic condition' for individuals in the 'increased risk' and 'high risk' BMI categories compared to those in the 'acceptable risk' BMI category in each ethnic sub-group. Overall, Asians in the 'increased' and 'high' risk categories were two-and four-times more likely to report 'at least one cardiometabolic condition' compared to those in the 'acceptable risk' category. However, this effect was not consistent across sub-groups. Specifically, odds were

Discussion
While Asians are often studied as a broad group, the results of this study provide further evidence of the heterogeneity in the obesity-health relationship across Asian ethnicities. When compared to a common referent group (i.e. South Asians in the 'acceptable risk' weight category), the relationship between excess weight and poor cardiometabolic health is strongest in the Filipino and South Asian sub-groups. Within sub-groups, the association between 'increased' and 'high' risk BMI categories and 'at least one cardiometabolic condition' also varies and is highest among Chinese.

Asians are different from each other in their BMI and CVD risks
These analyses confirm previous findings that the classification of Asians as a homogenous group can mask health risk amongst diverse Asian populations [19,20,35]. Specifically, these results demonstrate that Asian sub-groups differed from each other in cardiovascular risk factors such as smoking, physical activity level, alcohol, BMI, high blood pressure, diabetes and heart disease. However, in fully adjusted models, only Filipinos had higher odds of 'at least one cardiometabolic condition' compared to South Asians, whereas Chinese and Arabs had lower odds, and no difference was observed in the other ethnic sub-groups. All Asian sub-groups had lower odds of diabetes compared to South Asians, except for West Asians and Koreans (where no difference was observed).
Two notable Canadian studies have examined ethnic differences in obesity and cardiovascular disease that corroborate our findings [16,18] populations. Overall, Chinese respondents had the most favourable cardiovascular risk factor profile, with 4.3% of the population reporting two or more major cardiovascular risk factors, followed Obesity and Cardiometabolic Health Risk in Asian-Canadian Sub-Groups PLOS ONE | www.plosone.org by the South Asian (7.9%), White (10.1%) and black (11.1%) respondents.
In the second study, Liu et al. pooled data from three cycles (2000, 2003 and 2005) of the CCHS to examine the prevalence of CVD and associated risk factors in the various Canadian ethnic groups [18]. The prevalence of cardiovascular risk factors in this study is consistent with the Liu paper. Compared to White individuals, people from most visible minorities were less likely to smoke, more likely to be physically inactive, and were less likely to be obese. After adjustment for socio-demographic characteristics and chronic conditions, Liu et al. found that diabetes and hypertension were significantly more prevalent amongst South Asians (adjusted OR 2.17 for diabetes and 1.18 for hypertension), Filipino or South-East Asian respondents (adjusted OR 1.58 for diabetes and 1.54 for hypertension) than White respondents. No differences were seen for other Asian ethnicities as compared to Whites.

Ethnic variation in health risk associated with obesity
Building on the work of others [16,18], this study examines the relationship between obesity and cardiometabolic risk among Asian sub-groups in Canada. In the present study, when all Asian sub-groups were collapsed, those within the 'increased' or 'high' BMI categories were 2-to 4-times more likely to have 'at least one cardiometabolic condition'. When analyses were repeated within each Asian ethnic group, differences emerged. Most strikingly, the relationship between BMI and 'at least one cardiometabolic condition' was strongest in Chinese, resulting in 3.6 and 9 times greater odds in the 'increased' and 'high' risk BMI categories, respectively.
Our results are consistent with other literature on the effect of obesity on cardiovascular health risk in Asian populations [36][37][38][39][40][41][42][43][44][45][46]. Several studies have shown that the association between BMI and cardiometabolic risks is steepest in Chinese compared to other ethnicities [38,41,46]. For example, Katz et al. showed that the adjusted incidence difference for hypertension per 1000 persons in young adults with a BMI of 25 vs. those of BMI of 21 was 83 for Chinese, 50 for Blacks and 30 for Whites. Amongst middle-aged adults, similar patterns are seen, with incidence differences of 137 for Chinese, 49 for Blacks, and 54 for Whites [41].
There are several possible explanations for the observed differences in the relationship between obesity and cardiometabolic risk factors between Asian ethnic sub-groups. Both environmental and genetic factors are likely to be important in determining CVD risk. Lifestyle changes and increasing affluence have led to a high prevalence of obesity, insulin resistance, T2DM and CVD among Asians living in the West. However, previous research indicates that differences in CVD cannot be explained by differences in conventional cardiovascular risk factors alone [47]. Having adjusted for these modifiable/behavioural characteristics in this study, other factors such as differences in the relationship between BMI, BF%, and health are potential contributors to the observed differences.
Differences in the association between excess weight and cardiometabolic health risks among Asian sub-groups may is attributed in part to differences in BMI-Fat Mass (FM)% as a result of differences in body build and/or frame size. BMI does not distinguish between individuals or populations who have very long or short legs relative to torso length, and BMI will tend to underestimate obesity amongst those with long legs and over estimate obesity among those with short legs relative to torso length [3,48,49]. It is well known that ethnic groups differ in frame size and in relative leg length (relative sitting height) and that his has an impact on BMI [3,11,48,[50][51][52]. The distribution of body Table 3. Multivariable-adjusted odds ratios of 'at least one cardiometabolic condition' for Asian sub-groups compared to South Asians.  fat is also different in Asians compared with Europeans whereby Asians show a greater proportion of visceral abdominal tissue (VAT) for a given total body fat [53][54][55][56][57][58][59][60][61]. In turn, VAT has been shown to be an independent risk factor for CHD, hypertension, T2DM and impaired glucose tolerance [4,51,53,55,[62][63][64]. Several recent studies provide further insight into differences in body composition and health risk in Asian sub-groups. In the Multicultural Community Health Assessment Trial (M-CHAT) [13,65], while BMI and WC were highly correlated with total and regional measures of adiposity in each ethnic group, at any BMI, Chinese participants had a similar FM% to that of Europeans, whereas South Asians had 3.9% more. Above a WC of 71 cm, Chinese participants had considerably more VAT than European-Canadians, whereas South Asians had significantly more VAT than Europeans at all but the most extreme WC category (.105 cm) [13,65].

Strengths and limitations
Notable strengths of the current analysis include the use of a large, nationally representative sample, disaggregated into each Asian sub-group, and the inclusion of important socio-demographic and lifestyle variables associated with obesity and cardiovascular risk factors. Unlike previous studies that have used the 'White' population as the referent group, the current analysis opted for an internal comparison group within the broader 'Asian' categorization, as even among persons classified as ''White'', there is considerable variation in factors such as country of origin, birth cohort, and acculturation that may confound the relationship between obesity and health risk [37,66]. By using the more sensitive WHO cut-points for BMI in Asians, this analysis is able to capture variations in health risk that might otherwise have been missed. There are also several limitations that need to be noted. First, given that the CCHS relies on self-reported data, there is potential for both recall and healthy responder bias. For example, the possibility of under-reporting BMI (via an underestimation of weight among females and an overestimation of height amongst males) cannot be excluded [67]. Reporting of obesity may also vary by ethnicity, along with differences in the way people experience and label diseases, symptoms, and various lifestylerelated behaviours. The underestimation of chronic conditions by participants is also a possibility, but would have biased our results towards the null. The limitations of using BMI cut-offs are also well known [49,51,68,69]; however, due to the relative ease of use [70] and high specificity and validity [71,72], BMI may be considered a reasonable proxy of weight-related health risk in population-based studies [73,74]. Furthermore, type of diabetes was not differentiated. Finally, despite the large overall sample size used in this study, analyses for heart disease within obese categories of some ethnic groups had to be suppressed, whereas others may be underpowered to detect a difference.

Conclusion
Results of this study provide additional insight into the relationship between obesity and cardiovascular health across Asian sub-groups, as the appropriate classification of sub-populations is necessary if the mechanisms underlying such differences in health risk are to be understood and monitored. When taken together, higher odds of CVD associated with overweight and obesity for the Chinese, Filipino and South Asian groups, and the steeper association between excess adiposity and cardiovascular risk in Chinese, has important public health implications for targeted screening and culturally-specific interventions focusing on susceptible Asian-ethnic communities.