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Fig 1.

Regions of interest and associated regions.

Fig 1 displays regions of interest (nucleus accumbens [orange], amygdala [green], and anterior insula [blue; includes short insular gyrus, anterior segment of the circular sulcus of the insula, horizontal ramus of the anterior segment of the lateral sulcus, and vertical ramus of the anterior segment of the lateral sulcus]) and the brain stem (pink).

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Table 1.

Amygdala-nucleus accumbens associations.

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Table 2.

Amygdala-anterior insula associations.

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Fig 2.

Tripartite association network.

Fig 2 displays the tripartite association network between indole metabolites, clinical and behavioral measures, and functional and anatomical connectivity of the amygdala-NAcc circuit and the amygdala-aINS circuit. All significant (p < .05) associations are included in this visualization. Functional brain connectivity of regions of interest is presented with the region of interest noted in a larger font, with the connectivity measure and lateralization indicated below in the form X_Y, where X indicates a connectivity measure (B, Betweenness centrality; S, Degree strength) and Y indicates lateralization (L, Left; R, Right). Abbreviations: aINS, anterior insula; ALSHorp, horizontal ramus of the anterior segment of the lateral sulcus (aINS); ALSVerp, vertical ramus of the anterior segment of the lateral sulcus (aINS); Amg, amygdala; ANX, Hospital anxiety and depression (HAD) scale anxiety score; BMI, Body mass index; IAA, Indoleacetic acid; NAcc, nucleus accumbens; ShoInG, short insular gyrus (aINS); YFAS, Yale food addiction scale score.

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