Fig 1.
Flowchart of participant selection.
Fig 2.
Schematic workflow of image preprocessing.
Table 1.
Baseline clinical characteristics of the study participants.
Table 2.
Clinical variables by MRI acquisition time.
Table 3.
Regional ΔT1 values compared by MRI acquisition time.
Table 4.
Linear regression analysis of age and regional ΔT1 values by scan time.
Fig 3.
Scatterplots of ΔT1 versus age in the cerebral cortex.
Scatterplots depict the relationship between age (x-axis) and change in T1 relaxation time (ΔT1, y-axis) across four distinct cortical regions. In each plot, data points and their corresponding linear regression lines are stratified by scan time: daytime (blue) and nighttime (gray). Across all regions, a consistent negative correlation indicates that GBCA enhancement becomes more pronounced with increasing age, a trend irrespective of scan time.