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Fig 1.

Plot of univariate Regression-Discontinuity-Design.

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Fig 2.

Plot of the LMM-RDD for the special case of j = 1,2.

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Fig 3.

Flowchart of study and analysis population.

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Table 1.

Sociodemographic and clinical patient characteristics for analysis population and the population within the bandwidth (HADS between 13 to 16) for the primary analysis of the RDD.

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Table 2.

Results of the univariate and the linear mixed model RDD.

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Table 2 Expand

Fig 4.

Scatter plot (four panels) of the linear mixed model regression discontinuity design and the estimated time effect () for the comparison of the patients’ outcome HADS scores at T2 (after 4 months) and T3 (after 12 months of treatment).

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