Table 1.
Human resource costs referenced from the basic survey on wage structure.
Table 2.
Comparison of clazosentan use between patients with and without cerebral vasospasm.
Fig 1.
Treatment process for acute subarachnoid haemorrhage.
Values in parentheses indicate the time required for each procedure (minutes). D, doctor; N, nurse; R, radiographer; CT, computed tomography; CTA, computed tomography angiography; MRI, magnetic resonance imaging; SPD, spinal drainage; CVC, central venous catheter; DSA, digital subtraction angiography; FH, fasudil hydrochloride. #, coiling; ¶, without clazosentan.
Fig 2.
Decision tree model for the treatment of aneurysmal subarachnoid haemorrhage.
Half of the patients received clazosentan following coiling or clipping and subsequently transitioned to either recovery or symptomatic cerebral vasospasm (sVSP), based on the probabilities indicated at each node (black circles). Claz, clazosentan.
Table 3.
Parameters in the care process.
Table 4.
Total cost and difference for groups with and without clazosentan for patients with and without spasms under different treatments.
Fig 3.
Total cost differences for patients treated with and without clazosentan across two treatment modalities: Coiling (left) and clipping (right).
Table 5.
Cost differences among doctors, nurses, and radiographers in groups with and without clazosentan.
Fig 4.
Changes in labour costs for doctors, nurses, and radiographers in groups with and without clazosentan.
Changes are shown separately for coiling (left) and clipping (right).
Table 6.
Cost differences for the three experience levels of doctors in groups with and without clazosentan.
Table 7.
Sensitivity analysis of procedure time and labour costs.
Fig 5.
Impact of clazosentan effectiveness on total cost.
Each data point represents results for 10,000 hypothetical patients undergoing each treatment pathway as modelled in the decision tree. This process was repeated with 1,000 iterations to estimate the mean and 95% credible intervals. Claz, clazosentan; sVSP, symptomatic vasospasm; SD, standard deviation.
Fig 6.
Distribution of labour costs by professional role.
Left: coiling results. Right: clipping results. Top row: doctors; middle row: nurses; bottom row: radiographers. Claz, clazosentan; sVSP, symptomatic vasospasm; SD, standard deviation.
Fig 7.
Distribution of labour costs by physician experience level.
Left: coiling results. Right: clipping results. Top row: residents; middle row: specialists; bottom row: trainers. Claz, clazosentan; sVSP, symptomatic vasospasm.