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Table1.

Characteristics of included studies.

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Fig 1.

Study inclusion plot.

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Fig 2.

Results of single-arm meta-analysis on ICI monotherapy or combination therapy.

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Fig 3.

Hepatotoxicity of ICI monotherapy vs MKI/placebo at any grade.

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Fig 4.

Hepatotoxicity of ICI monotherapy vs MKI/placebo at grade

≥3.

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Fig 4 Expand

Fig 5.

Hepatotoxicity of combination immunotherapy vs ICI monotherapy/MKI at any grade.

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Fig 5 Expand

Fig 6.

Hepatotoxicity of combination immunotherapy vs ICI monotherapy/MKI at grade

≥3.

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Fig 6 Expand

Fig 7.

Grade

≥3 Hepatotoxicity in different combination immunotherapy regimens vs ICI monotherapy/MKI.

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