Table 1.
Brief description of the genome-wide association study data used in this study.
Fig 1.
Design and workflow of the Mendelian randomization study of the causal relationship between sex hormone binding globulin (SHBG) and infertility.
IVW, inverse variance weighted; MR, Mendelian randomization; MR-PRESSO, MR pleiotropy residual sum and outlier; SNP, single-nucleotide polymorphisms.
Table 2.
MR results on sex hormone binding globulin (SHBG) and infertility.
Fig 2.
Funnel plots illustrating the causal relationship between sex hormone binding globulin (SHBG) and infertility.
(A) Funnel plot for the causal association between SHBG and female infertility (B). Funnel plot for the causal association between SHBG and Female infertility associated with anovulation.
Fig 3.
Leave-one-out plots for the causal relationship between sex hormone binding globulin (SHBG) and infertility.
(A) Leave-one-out plots for the causal relationship between SHBG and female infertility. (B) Leave-one-out plots for the causal relationships between SHBG and female infertility associated with anovulation.
Table 3.
Cochran’s Q test results on sex hormone binding globulin (SHBG) and infertility.
Table 4.
Egger intercept analysis of sex hormone binding globulin (SHBG) and infertility.
Fig 4.
Potential mechanisms by which SHBG may cause infertility.