Table 1.
Results of multiple regression analysis for sources of variation of RVs.
Table 2.
SDR for the magnitude of sex and age -related changes in hematology RVs.
Table 3.
SDR for the magnitude of sex and BMI -related changes in hematology RVs.
Fig 1.
Between-gender differences for major parameters.
Gender-specific distributions of RVs for major parameters are drawn by scattergrams. The background shades represent RIs determined for male (blue), female (pink), and for both (purple). The central 50% range and median of RVs are shown by the horizontal box and the vertical line.
Fig 2.
Hematology RVs influenced by BMI and age.
RVs of RBC, Ret, Ret%, and IFR were partitioned by gender and BMI into five groups, while RVs were partitioned by age at 45 years. The central 50% range and median of RVs are shown by the horizontal box and the vertical line. No secondary exclusion was done while drawing the scattergrams.
Fig 3.
The effect of LAVE on RIs for hematology tests in comparison to IDA criteria.
Female RIs of 6 representative hematology tests were determined parametrically using the following 4 sets of RV datasets. 1: All: RVs without any prior exclusion. 2: LAVE(-) 7RT: RVs with no abnormal value among 7 tests (Hb, MCH, MCHC, RDW-CV, Ret, Fe, Ferr) other than itself. 4: LAVE(-) 5RT: RVs with no abnormal value among 5 ref tests (Hb, MCH, MCHC, RDW-CV, Ret) other than itself. 6: IDA(-): RVs with no abnormal results for Fe and Ferr from respective lower limit of the manufacturer’s RI. Each bar shown over the scattergram represents the span of RI with its lower and upper limits indicated by numerical labels. Please note that RIs indicated by green shade (at the 4th row) correspond to what we adopted in this study. The three scattergrams of RVs shown in red dots in the 3rd, 5th, and 7th rows represent values that were excluded by the criteria applied to obtain RVs shown above in the 2nd, 4th, and 6th rows in green. Thus, their group labels were designated as follows: As a reference, the following three datasets were prepared and plotted in the 3rd, 5th, and 7th row. 3: LAVE(+) 7RT: RVs with one or more abnormal values among 7 ref tests (Hb, MCH, MCHC, RDW-CV, Ret, Fe, Ferr). 5: LAVE(+) 5RT: RVs with one or more abnormal values among 5 ref tests (Hb, MCH, MCHC, RDW-CV, Ret). 7: IDA(+): RVs had abnormal results either for Fe or Ferr.
Table 4.
The list of RIs adopted for hematological parameters by sex and age.
Fig 4.
A Between-country comparison of RIs for erythrocyte and iron markers. B Between-country comparison of RIs for leukocyte parameters. Russia*—indicates RIs from the current Russian study; Russia (without *)–indicates RIs from the Russian Methodological Guidelines [33, 34]. The back shades indicate Russian RIs for male (blue), female (pink), and both genders (purple).
Table 5.
Comparison of RIs from this study with those from other studies.
Table 6.
Comparison of RIs from this study with those from other studies.