Fig 1.
Schedule of enrollment, interventions, and assessments.
Table 1.
Sample size estimation based on preliminary date.
*Assumes n = 125 per group complete cases and α = 0.05; r-squared of 5 covariates is 0.30, **The smallest mean difference necessary to ensure > 80% power, assuming pooled SD observed in the pilot.
Fig 2.
Conceptual model.
Table 2.
Stress-related candidate genes and functions.
Fig 3.
Plot of mean simulated power with 95 percentile (2.5 & 97.5%) for select DNAm differences.