Fig 1.
Study flowchart. CIS: clinical isolated syndrome; f/u: follow-up; IVMP: intravenous methylprednisolone; MS: multiple sclerosis; OCT: optical coherence tomography; ON: optic neuritis; VA: visual acuity.
Table 1.
Demographic and clinical data for patients with optic neuritis.
Fig 2.
The distribution of average retinal nerve fiber layer (RNFL) thickness (2a) and high-contrast best -corrected acuity (HC-BCVA) (2b) in patients with CIS- or MS optic neuritis.
2a: the average RNFL thickness of the affected eye compared to that of the unaffected eye (in %), and 2b: the HC-BCVA in LogMAR at final follow-up (difference from nadir). Left boxplots, red: patients treated with intravenous methylprednisolone without oral prednisone taper (No OPT). Right box plots, blue: patients treated with intravenous methylprednisolone with oral prednisone taper (With OPT). Box plot details: thick horizontal bar: median Box: interquartile range (25%–75%) Whiskers: range. Dots: outliers (data>1.5 times the interquartile range off the box). The violin plot in the background visualizes a smoothened density estimate.
Table 2.
Visual acuity and retinal nerve fiber layer characteristics at nadir and follow-up.
Table 3.
Linear regression model analysis for the retinal nerve fiber layer in the optic neuritis-affected eye compared to the unaffected eye (in %).
Table 4.
Linear regression model of visual acuity differences of affected eye from nadir to follow-up.