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Fig 1.

Method of journal papers’ selection.

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Fig 2.

Number of released papers targeting IG and GA for cancer research.

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Fig 3.

Number of released papers targeting mRMR and PSO for cancer research.

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Table 1.

Comparison of the different parameters in previous work.

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Table 2.

Gene expression datasets used in the investigations.

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Fig 4.

Class label distribution for the colon cancer datasets.

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Fig 5.

PCA for exploring the data structure of the datasets.

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Fig 6.

The proposed framework model–HMLFSM.

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Table 3.

The number of relevant genes (features) selected by the proposed model on each phase.

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Fig 7.

Classification accuracy for the ML algorithms applied to Dataset 1.

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Fig 8.

ML confusion matrix for the ML algorithms applied to Dataset 1.

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Fig 9.

ROC area for the ML algorithms applied to Dataset 1.

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Fig 10.

Classification accuracy for the ML algorithms applied to Dataset 2.

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Fig 11.

Confusion matrix for the ML algorithms applied to Dataset 2.

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Fig 12.

ROC area for the ML algorithms applied to Dataset 2.

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Fig 13.

Classification accuracy for the ML algorithms applied to Dataset 3.

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Fig 14.

ML confusion matrix for the ML algorithms applied to Dataset 3.

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Fig 15.

ROC area for the ML algorithms applied on Dataset 3.

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Fig 16.

Summary of ROC area for the ML algorithms applied to all datasets.

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Table 4.

Phase 1 performance measures for Dataset 1.

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Table 5.

Phase 1 performance measures for Dataset 2.

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Table 6.

Phase 1 performance measures for Dataset 3.

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Table 7.

Phase 2 performance measures for Dataset 1.

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Table 8.

Phase 2 performance measures for Dataset 2.

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Table 9.

Phase 2 performance measures for Dataset 3.

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Table 10.

Comparison of the proposed model, with others in the literature.

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