Fig 1.
Cognitive task protocol used for the NIRSIT system.
SVFT, semantic verbal fluency task.
Fig 2.
Schematic channel position on normalized brain atlas.
Table 1.
The number of subjects in the full data set who had measurements from each domain.
Table 2.
Clinical characteristics of patients.
Table 3.
Comparison of neuropsychological test results of the groups.
Fig 3.
fNIRS activation (t-values) during the SVFT task, where the warmer color indicates a greater activation.
The ventral part of the PFC involving the bilateral orbitofrontal cortex showed significant activation. fNIRS: Functional near-infrared spectroscopy, SVFT, semantic verbal fluency task, PFC: Prefrontal cortex.
Fig 4.
fNIRS group effect map (F-values) showing differential group activation during SVFT, where the warmer color indicates greater group difference.
The dorsal part of the PFC involving the bilateral dorsolateral cortex shows a significant group effect. fNIRS: Functional near-infrared spectroscopy, SVFT, semantic verbal fluency task, PFC: Prefrontal cortex.
Fig 5.
Comparison of the mean ΔHbO2 during SVFT between groups.
SVFT, semantic verbal fluency task.
Table 4.
The LME model result indicates the mean ΔHbO2 from the bilateral DLPFC regions showing a significant positive correlation to the overall FDG-PET.
Fig 6.
The group effect on Amyloid-PET in the temporal lobe and the mean ΔHbO2 from the two fNIRS ROIs.
PET: Positron emission tomography, fNIRS: Functional near-infrared spectroscopy, ROI: Region of interest.
Fig 7.
The MANCOVA on the right hippocampal gray volume and right DLPFC fNIRS.
MANOVA: Multivariate analysis of covariance, DLPFC: Dorsolateral prefrontal cortex, fNIRS: Functional near-infrared spectroscopy.
Fig 8.
MANCOVA test on the frontal cortical thickness and fNIRS.
LME: Linear mixed effect (LME), MANOVA: Multivariate analysis of covariance.