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Fig 1.

PRISMA flow diagram depicting study selection algorithm.

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Table 1.

Characteristics of all studies included in the review.

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Table 2.

Cut-off value, sensitivity, specificity, AUC and other observation indexes for NSE, S100B, NFL, IL-6, DD and coagulation factor activity R.

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Fig 2.

(A) Forest plot of NSE predicting neurological complications at 24 hours after operation. (B) Forest plot of the pooled result after corrected by the different types of surgery according to the sensitivity analysis.

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Fig 3.

(A) Forest plot of S100B predicting neurological complications at 6 hours after operation. (B) Forest plot of S100B predicting neurological complications at 24 hours after operation. (C) Forest plot of the pooled result after corrected by the sensitivity analysis.

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Fig 4.

(A) Forest plot of S100B predicting neurological complications at 6 and 24 hours after operation. (B) Forest plot of the pooled result after corrected by the sensitivity analysis.

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Table 3.

Summary of meta-analysis results.

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