Fig 1.
MR-images and tumor tissue of an exemplary patient at initial diagnosis (first row) and first tumor progression (second row). T1-weighted contrast-enhanced images (a and d), cerebral blood volume (CBV) maps as transparent overlays on the T1-weighted contrast-enhanced images (b and e) and hematoxylin and eosin (HE) stained tumor tissue (c and f) are shown. Color bars in b and e display the CBV range. Arrows in c and f indicate exemplary vessels within the tumor. Both the CBV and the vessel density in the tumor were notably higher at the initial diagnosis in comparison to the first progression.
Table 1.
Patient and tumor characteristics (n = 65).
Fig 2.
rCBVmax at initial diagnosis and progression.
Relative cerebral maximum blood volume in the tumor (rCBVmax) significantly (p < .01) decreasing from initial diagnosis to first progression displayed as box-plots (whiskers indicate the standard deviation, the horizontal line within the boxes indicates the mean) (a) and missing correlation (Spearman’s rho = .12) of the rCBVmax values at initial diagnosis and first progression displayed as scatter plot with regression line (b).
Fig 3.
Vessel densities and corresponding rCBVmax in patients with available tumor tissue (n = 24).
Maximum vessel densities in the tumor (1/mm2, a) and corresponding relative cerebral maximum blood volume in the tumor (rCBVmax, b) significantly (p = .01/p < .01) decreasing from initial diagnosis to first progression displayed as box-plots (whiskers indicate the first and third quartile for a and the standard deviation for b, the horizontal line within the boxes indicates the median for a and the mean for b) for the subgroup of patients with available tumor tissue at both timepoints (n = 24). Missing correlations (Spearman’s rho = .07/.26) of the maximum vessel densities in the tumor (1/mm2, c) and the corresponding rCBVmax values (d) at initial diagnosis and first progression depicted as scatter plot with regression line.