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Fig 1.

Graphical abstract.

A graphical depiction of the study concept and main findings. Created with BioRender.com.

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Table 1.

Baseline clinical characteristics of the LOOP study.

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Table 1 Expand

Table 2.

Comparison between LOOP study and Copenhagen City Heart Study.

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Table 2 Expand

Fig 2.

Diagram of abnormal left ventricular geometry and systolic function.

The figure shows the prevalence of left ventricular hypertrophy, abnormal GLS, and abnormal LVEF as well as the overlap between the different groups. The percentages represent the proportion according to the total population in whom GLS was obtainable (n = 1,378). GLS: global longitudinal strain, LVEF: left ventricular ejection fraction.

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Fig 2 Expand

Table 3.

LV functional abnormalities in the population and subgroups without CAD in the LOOP study.

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Table 3 Expand

Table 4.

LV functional abnormalities in risk groups with preserved LVEF without CAD in the LOOP study.

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Table 5.

Subclinical LV and LA abnormalities in subgroup with normal LAVi and LVEF and no CAD in the LOOP study.

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Fig 3.

Diagram of diastolic dysfunction and abnormal left atrial size and function.

The figure shows the prevalence of diastolic dysfunction, dilated LA, and abnormal LA strain as well as the overlap between the different groups. The percentages represent the proportion according to the total population in whom LA strain was obtainable (n = 1,421). LA: left atrium.

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Fig 3 Expand

Table 6.

LV functional abnormalities according to MAC in the LOOP study.

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Table 6 Expand