Fig 1.
Flow chart of the formation of the three studied patient groups.
Table 1.
Patient characteristics per pathogen group.
Table 2.
Distribution of causative microbial agents per pathogen group for statistical data analysis.
Fig 2.
Schematic representation of stratified nested cross-validation for elastic net regression model optimization and performance [21].
Abbreviations: CV: cross-validation.
Fig 3.
ROC curves of the results from logistic regression and elastic net regression models that were tested in five-fold cross-validation with 100 repeats for the comparisons: atypical versus S. pneumoniae and viral pathogens; S. pneumoniae pathogens versus atypical and viral pathogens; and viral versus S. pneumoniae and atypical pathogens.
Abbreviations: LR: logistic regression, EN: elastic net regression, SDMA: symmetric dimethylarginine, LPI (18:1): lysophosphatidylinositol (18:1).
Table 3.
Results from the logistic regression and elastic net regression models that were tested in a fivefold cross-validation with 100 repeats.
Fig 4.
Variable importance of metabolites for the prediction of an atypical bacterial infection versus S. pneumoniae and viral infections.
Only metabolites with an absolute mean percentage of influence > 1% are visualized.