Table 1.
Composition of the four perfusion solutions.
Fig 1.
Schematic figure of the normothermic perfusion circuit.
Table 2.
Baseline information.
Fig 2.
Renal arterial flow (ml/min/100g) of the four experimental groups during NMP (mean + SD).
Table 3.
Functional and injury parameters throughout perfusion.
Fig 3.
Cumulative diuresis (ml) (A) and AUC (B) of the four experimental groups during NMP (mean + SD).
** indicates a p-value of ≤ 0.01. *** indicates a p-value of ≤ 0.001.
Fig 4.
Sodium and potassium levels (mmol/L) of the four experimental groups during NMP (mean + SD).
Fig 5.
pH of the four experimental groups during NMP (mean + SD).
Fig 6.
Mean creatinine clearance (ml/min) (A), AUC of creatinine clearance (B), mean fractional excretion of creatinine per 100g (FE creatinine/100g) (C), AUC of FE creatinine (D), mean fractional excretion of sodium (FENa+) (E), and AUC of FENa+ (F) of the four experimental groups during NMP (+ SD).
* indicates a level of significance of p ≤ 0.05.
Fig 7.
ASAT levels (U/l) (A), AUC of ASAT (B), LDH levels (U/l) (C), and AUC of LDH (D) of the four experimental groups during NMP (mean + SD).
* indicates a level of significance of p ≤ 0.05.
Fig 8.
Mean NAG levels (U/L) (A) and AUC of NAG (B), mean MDA levels (uM) (C), and AUC of MDA (D) of the four experimental groups during NMP (+ SD).
* indicates a level of significance of p ≤ 0.05. ** indicates a p-value of ≤ 0.01. *** indicates a p-value of p ≤ 0.001.
Fig 9.
Scores on necrosis, tubular and glomerular dilatation at t = 0 and t = 420 (mean + SD).
Fig 10.
Bax (A) and Bcl-2 (B) levels at t = 0 and t = 420 (mean + SD). Bax/Bcl-2 ratios (C) are displayed per group.
* indicates a level of significance of p ≤ 0.05. ** indicates a p value of ≤ 0.01. *** indicates a p value of p ≤ 0.001.