Fig 1.
Flowchart of the selected study population.
Abbreviations: AF = atrial fibrillation, AF Risk = AF Risk study, Biomarker AF = Biomarker AF study, GGAF = Groningen Genetic Atrial Fibrillation study, GIPS III = glycometabolic intervention as adjunct to primary percutaneous coronary intervention in ST elevation myocardial infarction III study, IBD = identity by descent, PREVEND = Prevention of Renal and Vascular End-stage Disease study, QC = Quality control, Young AF = Young AF study.
Fig 2.
Sex-differences in clinical characteristics.
Results of Chi-squared test p < 0.1 are given. The asterisk (*) indicates statistical significance (p < 0.05). Abbreviations: COPD = chronic obstructive pulmonary disease, TIA = transient ischemic attack.
Table 1.
Characteristics of the AF patients in the GGAF cohort.
Fig 3.
Characteristics of weight and AF progression in BMI Genetic Risk Score tertiles of both men and women.
In this figure the distribution of obesity, overweight and normal weight and AF progression in the BMI genetic risk tertiles are displayed in percentages. Abbreviations: AF = atrial fibrillation, BMI = body mass index.
Fig 4.
Overview of AF progression in the GGAF cohort.
On the left side of Fig 2 AF type and numbers (percentages) at baseline are shown. On the right side of Fig 2 AF type and numbers (percentages) at follow-up are shown. The orange lines represent the transition to AF progression, the blue lines represent no progression. Abbreviations: AF = atrial fibrillation.
Fig 5.
The association between the BMI Genetic Risk Score and AF progression in men and women.
*Adjusted for principal components, age at inclusion, AF type at baseline, follow-up duration, BMI, hypertension, age > 75 years, transient ischemic attack or stroke, chronic obstructive pulmonary disease, heart failure, and peripheral vascular disease. Abbreviations: BMI = body mass index.