Fig 1.
A flowchart illustrating the ultrasound image selection procedure.
Table 1.
Different AmCAD-UT settings adjustment for comparative analysis of diagnostic performance.
Fig 2.
AmCAD-UT diagnosis output from different TIRADS for a cytologically benign nodule.
Fig 3.
ROC curve demonstrating the diagnostic performance of the 6 TIRADS at the default setting.
Fig 4.
PRC curve demonstrating the diagnostic performance of the 6 TIRADS at the default setting.
Table 2.
AmCAD-UT Diagnostic performance at different adjusted settings.
Table 3.
Pairwise comparison of TIRADS diagnostic performance in CAD-differentiation of malignant and benign thyroid nodules at different settings.
Fig 5.
An example of a thyroid nodule misdiagnosed as false negative for malignancy.
The misdiagnosis was based on the software’s impression of the hyperechoic and homogenous sonographic features. The histopathological diagnosis of the nodule was papillary thyroid cancer.
Fig 6.
An example of a solid markedly hypoechoic thyroid nodule that was diagnosed as false positive.
The nodule was also taller than wide with echogenic foci. The impression of these suspicious sonographic features led to the misdiagnosis by the different TIRADS within the AmCAD-UT software. The nodule was diagnosed as benign with cytology.