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Fig 1.

Sample collection flow diagram.

Flow diagram of biological sample collection, and study sample inclusion.

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Table 1.

Variable summary of potential predictors of RNA quality.

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Table 1 Expand

Table 2.

Summary of RNA quality outcomes.

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Table 2 Expand

Fig 2.

RNA purity t-test results.

Paired t-test comparing mean RNA purity (260/280 optical absorbency ratios) in the 2011 and 2018 RNA isolations.

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Fig 3.

RNA yield t-test results.

Paired t-test comparing mean RNA yield in the 2011 and 2018 RNA isolations.

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Fig 4.

RNA purity linear regression results.

Association between the difference in RNA purity (2011 260/280 ratio minus 2018 260/280 ratio) and length of storage time. The negative slope implies that the difference between 2011 and 2018 increased with storage time, with the 2018 purity increasing over time.

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Fig 5.

RNA yield linear regression results.

Association between the difference in RNA quantity (2011 μg /tube minus 2018 μg /tube) and length of storage time. The negative slope implies that the difference between 2011 and 2018 increased with storage time, with the 2018 quantity increasing over time.

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Fig 5 Expand

Fig 6.

RNA integrity linear regression results.

Association between the RNA integrity number and length of storage time.

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Fig 6 Expand