Table 1.
Patient demographics and clinical characteristics.
Table 2.
Physician reports of risk classification guidelines referenced in their risk assessments.
Fig 1.
Physician-reported patient risk classification versus A. COMPERA [8], B. non-invasive FPHR [9], and C. REVEAL 2.0 [7].
The COMPERA (A) and FPHR (B) methods use thresholds suggested by ESC/ERS pulmonary hypertension guidelines. The non-invasive FPHR method requires BNP values; 120 patients had available BNP values. The REVEAL 2.0 method (C) requires patients to have complete data for age, sex, etiology, vitals (BP and pulse), eGFR or renal insufficiency, NT-proBNP, NYHA FC, 6MWD, and recent hospitalizations; 119 patients had available data. Red boxes indicate where patients were rated as higher risk by the objective methods than by physicians. 6MWD, 6-minute walking distance; BNP, brain natriuretic peptide; BP, blood pressure; COMPERA, Comparative, Prospective Registry of Newly Initiated Therapies for Pulmonary Hypertension; eGFR, estimated glomerular filtration rate; FPHR, French Pulmonary Hypertension Registry; inter., intermediate; NT-proBNP, N-terminal pro-brain natriuretic peptide; NYHA FC, New York Heart Association functional classification; pts, patients; REVEAL, Registry to Evaluate Early and Long-Term PAH Disease Management.
Fig 2.
Factors associated with risk assessment incongruency.
(A) Frequency of echocardiographic monitoring was associated with incongruency such that patients with echocardiography every 3 months were less likely to have incongruency of risk assessment than those with echocardiography every 7 to 12 months (p = 0.01). There was no statistically significant difference in incongruency between patients with echocardiography every 3 months compared to those with echocardiography every 4 to 6 months (p = 0.069). (B) The physician-reported activity level was associated with incongruency such that patients with physician-reported high activity levels had more incongruencies than those with physician-reported low activity levels (p = 0.047).