Fig 1.
IBIT: Brazilian Institute for Tuberculosis Investigation (Reference Health Center); RHZ: Rifampicin (600mg), Isoniazid (400mg) and Pyrazinamide (2000mg). Dose to patients >45kg; RHEZ: Rifampicin (150mg), Isoniazid (75mg), Ethambutol (275mg) and Pyrazinamide (400mg) (fixed dose combination-FDC).
Table 1.
Baseline demographic and clinical presentation of tuberculosis patients.
Table 2.
Distribution and characteristics of adverse drug reactions (ADRs) of tuberculosis patients.
Fig 2.
Distribution of ADRs in TB patients.
(A) Frequency of ADRs in patients with RHZ and RHEZ anti- TB regime. (B) Outcomes treatment were compared between patients with RHZ and RHEZ anti-TB treatment. The significant p values are shown. (C) ADRs frequencies of anti-TB treatment groups with RHZ and RHEZ are shown. (D) ADRs distribution for systems were compared between patients with RHZ and RHEZ anti-TB treatment. The significant p-values are shown. Others: Hepatic, ocular, circulatory and respiratory system.
Table 3.
Treatment outcome and sputum smear result of tuberculosis patients.
Fig 3.
MDR-TB cases and crude and odds ratio for adverse drug reaction in tuberculosis patients.
(A) Total number of MDR-TB cases shown per year in Brazil, Salvador and IBIT (B) A multivariable regression model adjusted for RHEZ-FDC treatment, age ≥ 30 years, alcohol consumption and diabetes. The odds associated with the covariates used in the model adjustment are displayed in Table 3. OR = Odds ratio; CI = confidence intervals.