Fig 1.
Assessment of tumor-infiltrating lymphocytes (TILs) level.
(A) 5% of TILs (x200) (B) 20% of TILs (x200) (C) 60% of TILs (x200) (D) 80% of TILs (x200) (E) Area with aerosol spread was excluded. (x200) (F) Area with lepidic growth pattern was not included in assessment of TILs. (x200).
Fig 2.
Assessment of tertiary lymphoid structures (TLSs).
(A) Yellow colored arrow head indicates TLSs without germinal center around invasive tumor. (x40) (B) Blue colored arrow head indicates TLS with germinal center around invasive tumor (x40) and inset shows the magnified image of TLS (x200) (C) Absence of TLSs around invasive tumor (x12.5) (D) Abundant TLSs with germinal center (red asterick) around invasive tumor (x12.5).
Table 1.
Basic data of primary lung adenocarcinoma.
Table 2.
Clinicopathologic correlation according to level of TILs+.
Fig 3.
Survival analysis in resected lung adenocarcinoma.
(A) Overall survival according to tumor-infiltrating lymphocytes (TILs) level (B) Progression-free survival according to TILs level (C) Overall survival according to TILs level in early stage (stage I and II) disease (D) Overall survival according to TILs level in advanced stage (stage III and IV) disease (E) Progression-free survival according to TILs level in early stage (stage I and II) disease (F) Progression-free survival according to TILs level in advanced stage (stage III and IV) disease.
Table 3.
Univariate and multivariable analyses of overall survival and progression free survival.