Fig 1.
Flowchart of our search strategy and analysis.
Our search yielded a total of 3,727 registered otorhinolaryngology trials, of which 3,308 were excluded. In total 419 eligible otology trials were identified.
Fig 2.
Recruitment status and rate of publication of all otology trials registered in ClinicalTrials.gov.
Unknown status: a study on ClinicalTrials.gov which last known status was ‘recruiting’, ‘not yet recruiting’, or ‘active, not recruiting’ but that has passed its completion date, and the status has not been last verified within the past 2 years. Terminated: the study has stopped early and will not start again. Other: trials with recruitment status ‘withdrawn’, ‘suspended’, ‘enrolling by invitation’, ‘recruiting’ and ‘(active,) not yet recruiting’. For all data, see S1 Table.
Table 1.
Binary logistic regression for effect of different characteristics on publication of completed otology trials registered in ClinicalTrials.gov.
Fig 3.
Rate of publication after trial completion over time.
Results are shown for 335 completed trials. For six trials, no (primary) completion dates were reported. n = number of completed trials.
Fig 4.
Time to publication after trial completion over time.
Results are shown for 200 publications of completed trials. For three published trials, no (primary) completion dates were reported. *Publication before completion date. n = number of completed trials.