Fig 1.
Schematic description of the proposed method: (a) Disease progression network. (b) Disease progression chain by shortest path algorithm.
Fig 2.
Example of calculating similarity between diseases in ADN.
Fig 3.
Example of calculating weight between diseases in pDPN.
Fig 4.
Example of calculating weight between diseases in cDPN.
Fig 5.
Example of calculating weight between diseases in tDPN.
Fig 6.
Pseudocode for finding k-shortest paths.
Table 1.
Data description for experiments.
Table 2.
Result of construction of progression networks.
Fig 7.
Four-set Venn diagram of overlap of diseases and prior-posterior relations.
Fig 8.
Disease progression chains in integrated disease network.
Fig 9.
Spectrum of disease progression chains.
Fig 10.
Distribution of disease progression chain lengths among 3,302 diseases.
Table 3.
Verification of disease progression chains.
Fig 11.
Validation with distribution of ratio of relative risk for prior-posterior relations in disease progression chains: (a) the distribution of RRR of the prior-posterior relations. (b) the distribution of the average RRR for the disease progression chains.