Table 1.
Patient demographic and clinical characteristics.
Fig 1.
Example segmentations of the right (green) and left (red) thalamus from high-resolution anatomical T1-weighted MRI, for a PBC patient and a control subject.
Fig 2.
Thalamus volume is significantly reduced in both the left and right hemispheres in PBC patients compared to controls (*p < 0.03).
Fig 3.
ALFF (in arbitrary units) of the left thalamus is significantly reduced in PBC patients who did not respond to UDCA therapy (p = .05), relative to UDCA responders, who were the same as control subjects (CTRL).
ALFF of the right thalamus exhibited a strong trend (p = 0.055).
Fig 4.
ALFF (in arbitrary units) of the anterior insula is reduced in both the left and right hemispheres in PBC patients compared to controls (*p < 0.02).
Fig 5.
Fibroscan value is significantly associated with susceptibility (in parts per billion) within the left (p = 0.007) and right anterior insula (p = 0.013) of PBC patients.
Mean susceptibilities of the left and right anterior insula for the control subjects are depicted by the square markers (error bars represent standard error of the mean).