Fig 1.
Flow chart summarising the collection of RCT preparation costs.
Abbreviations: RCT, randomized clinical trial; ASPIRE, Adherence to SPIrit statement REcommendations.
Table 1.
Retrospectively estimated working times and costs to plan and prepare RCTs.
Table 2.
Sensitivity analysis results regarding retrospectively estimated working times and costs to plan and prepare RCTs.
Table 3.
Item-specific costs to prepare RCTs.
Table 4.
Time (in days) from submission of study documents of a planned randomized clinical trial until research ethics committee approval in 2012 and 2016.
Table 5.
Swissmedic approval times by year and sponsor for clinical trials (not exclusively randomized clinical trials).