Table 1.
Composition of parenteral nutrition tested (Source: Women and Children’s Hospital).
Table 2.
Composition of IV SMOFLipid admixture (Source: Women and Children’s Hospital).
Fig 1.
Methodology of study.
Fig 2.
Chromatogram of ibuprofen lysine at time 0 hours.
Fig 3.
Chromatogram of standard preterm PN at time 0 hours.
Fig 4.
Chromatogram of IV SMOFLipid admixture + vitamins at time 0 hours.
Table 3.
Ibuprofen stability data.
Fig 5.
Visual observation at time = 0 hours.
From left to right: Appearance of Ibuprofen 5 mg/mL diluted with 0.9% NaCl, ibuprofen 5 mg/mL mixed 1:1 with standard preterm PN 10%, ibuprofen 2.5 mg/mL mixed 1:1 with standard preterm PN 10% and ibuprofen 1.25 mg/mL mixed 1:1 with standard preterm PN 10%.
Fig 6.
Visual observation at time = 4 hours.
From left to right: Appearance of ibuprofen lysine 5 mg/mL diluted with 0.9% NaCl, ibuprofen 5 mg/mL mixed 1:1 with standard preterm PN 10%, ibuprofen 2.5 mg/mL mixed 1:1 with standard preterm PN 10% and ibuprofen 1.25 mg/mL mixed 1:1 with standard preterm PN 10%.
Table 4.
Appearance of ibuprofen lysine mixed with PN/glucose/IV SMOFLipid admixture at time = 0 hours.
Fig 7.
Ibuprofen 5 mg/mL + standard preterm PN.
Fig 8.
Change in pH over 4 hours in ibuprofen + PN/glucose combinations.
Table 5.
Change in mean particle diameter in IV SMOFLipid admixture and IV SMOFLipid admixture + ibuprofen combination.
Table 6.
Change in zeta potential in IV SMOFLipid admixture and SMOF lipid admixture + ibuprofen combination.
Table 7.
Change in ibuprofen concentration over 4 hours in ibuprofen + PN/IV SMOFLipid admixture.