Table 1.
Pre-operative characteristics in 906 patients who underwent surgery for suspected adnexal masses.
Table 2.
Diagnostic performance of serum fibrinogen and CA-125 to detect ovarian malignancy in 906 patients with adnexal masses.
Fig 1.
ROC-curves representing the accuracy for detection of ovarian malignancy in patients with adnexal masses for CA-125, fibrinogen, the full model (including fibrinogen, CA-125, malignancy-criteria on ultrasound), and the model without fibrinogen.
AUC = area under the curve.
Table 3.
Predictive factors for ovarian malignancy in uni- and multivariate logistic regression analyses of 906 patients who underwent surgical removal of their adnexal masses.
Fig 2.
Nomogram to predict ovarian cancer in patients with adnexal masses.
To use the nomogram, locate the patient’s variable on the corresponding axis; draw a line to the “score” axis, sum the scores, and draw a line from the “total score” axis to the “probability of malignancy” axis.
Fig 3.
Calibration plots for assessing the performance of the nomogram to predict ovarian cancer in patients with adnexal masses in (A) the test sample (n = 453) and (B) the validation sample (n = 453). In both (A) and (B), the dashed line represents the ideal reference line where the predicted probabilities estimated from the model would match the observed proportion of patients with ovarian cancer.
Fig 4.
Decision curve analysis of the effect of the presented nomogram for predicting ovarian cancer in patients with adnexal masses.
Assumption was made that the identification of ovarian cancer would lead to surgery. Net benefit of the presented nomogram is plotted against threshold probabilities for ovarian cancer compared with the strategies of treating all patients with adnexal masses or no one. The nomogram showed an improved net benefit between 5% and 90% threshold probability.
Table 4.
Net benefits for the nomogram to predict ovarian cancer in patients with adnexal masses.
Assumption was made that the identification of ovarian cancer would lead to surgery.