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Fig 1.

Study flow diagram.

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Table 1.

Basic characteristics of included studies.

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Table 1 Expand

Fig 2.

Results of QUADAS-2, Risk of bias and concerns regarding applicability.

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Fig 3.

Forest plot of pooled sensitivity.

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Fig 4.

Forest plot of pooled negative predictive value.

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Fig 5.

SROC curve.

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Table 2.

Summary of subgroup analysis by different clinical characteristics.

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Table 2 Expand

Fig 6.

Deeks' funnel plot with regression line.

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Fig 6 Expand