Table 1.
Demographic and clinical/radiological profiles of children with Angelman syndrome and controls.
Table 2.
The coefficients for the first three principle components and the variance explained.
Fig 1.
The two-dimensional biplot shows the projection of the data on the first two PCs.
It colors each point according to the gender and shows the loading of each variable on the first two principal components with a circle of correlation.
Fig 2.
A chart of the correlation matrix.
The distribution of each variable is shown on the diagonal. On the bottom of the diagonal: the bivariate scatter plots with a fitted line are displayed. On the top of the diagonal: the value of the correlation plus the significance level as stars. Abbreviations: CSF, cerebrospinal fluid; GM, grey matter; WM, white matter; PC, principal component.
Fig 3.
Between-group VBM analysis: the statistical map is overlaid on the study-specific grey matter template (created by FSL-VBM protocol) on axial plane.
Red-yellow clusters show grey matter volumetric reduction in children with Angelman syndrome compared to controls.
Table 3.
Size and labelled anatomical structures of the significant clusters (p < 0.05, corrected).
The voxel coordinates (in millimeter) in MNI standard space for the location of the maximum intensity are presented. The probability values are scaled from 0 to 100 and indicate the probability of the cluster being a member of the different labelled regions within the atlas.
Fig 4.
Single group VBM analysis with additional covariates (PCs): the statistical map represents the correlation between PC2 and GM volume in AS children overlaid on the study-specific grey matter template (created by FSL-VBM protocol) on the sagittal, coronal and axial plane.