Table 1.
Pre-treatment Patient Characteristics.
Fig 1.
Percent changes of pre-treatment versus SVR24 liver stiffness liver.
The figure shows the median percent change of LS for each METAVIR fibrosis stage stratified by the pre-treatment LS score.
Fig 2.
Pre-treatment versus SVR24 liver stiffness.
Comparison of pre-treatment to SVR24 LS in kPa stratified by METAVIR fibrosis stage with (A) depicting median and interquartile ranges for pre-treatment scores and (B) depicting median and interquartile ranges for SVR24 scores. The vertical axis is the liver stiffness in kPa and the horizontal axis is the METAVIR fibrosis stage and the number of patients in each fibrosis stage. The top and bottom boxes represent interquartile ranges (interquartile 1 and interquartile 3 respectively). The lines through the boxes represent median values. The whiskers at the end of the box represent the maximum and minimum values.
Table 2.
Estimated Fibrosis Stage using Fibroscan at SVR24 Stratified by the Pre-treatment Stiffness Score.
Table 3.
Median Change in LS from Pre-treatment to SVR24 Stratified by Pre-treatment Estimated Fibrosis Stage using FibroScan.
Table 4.
Changes in Liver Stiffness (pre-treatment to SVR24): IFN vs IFN-free Regimens.
Table 5.
Comparison of Pre-treatment and SVR24 Clinical Laboratory Values.
Table 6.
Linear Regression Analysis of the Percent Change in Liver Stiffness and the Change in Laboratory Values from Pre-treatment to SVR24.
Fig 3.
Liver stiffness changes during follow-up post-SVR24.
The graph shows FibroScan scores in 56 patients who had an additional measurement afterSVR24. 0 on the horizontal axis indicates SVR24. Stiffness decreased over time, but the change was not significant as demonstrated by linear regression with a p-value = 0.9. The colors indicate the pre-treatment fibrosis stage as estimated from the LS score, green (F0-1), yellow (F2), orange (F3), red (F4).
Fig 4.
Model of changes in liver stiffness overtime.
This model graph shows a percentage decrease in liver stiffness from pre-treatment to post-SVR24. The initial decline in liver stiffness is most likely due to regression of liver inflammation. After SVR24 there was little change in liver stiffness over time as indicated in Fig 3.