Table 1.
Demographics of study population.
Table 2.
Frequency (%) of signs and symptoms.
Table 3.
Spearman correlations of ordinal signs and symptoms of ETEC illness.
Fig 1.
Maximum number and volume of loose stools during any 24 hour period post-inoculation.
Footnote: Rectangles represent thresholds for mild, moderate and severe diarrhea.
Table 4.
Univariate regression between ETEC-attributable signs and symptoms and maximum 24 hour stool output.
Fig 2.
Multiple correspondence analysis of signs and symptoms of ETEC following experimental infection.
Fig 3.
A: Histogram of 3 component ETEC disease score relative to traditional diarrhea severity based on fixed cut points of stool output. B: Receiver Operator Curve comparing 3 component ETEC disease score to traditional primary endpoint of moderate-severe diarrhea based on stool output.
Table 5.
Disease severity score components.
Table 6.
Comparison of 3-component ETEC disease score in naïve and vaccinated subjects.