Table 1.
Characteristics of patients at their inclusion (A1) in the MIG-HD and RIL-HD trials.
Fig 1.
Impact of the retest effect in the MIG-HD cohort.
SDMT: Symbol Digit Modalities Test; Stroop C, W and C/W: Stroop color, word and color/word interference; MDRS: Mattis Dementia Rating Scale; TMT A, B: Trail-Making Test A and B; TFC: Total Functional Capacity; IS: Independence Scale; FAS: Functional Assessment Scale. The red curve represents the baseline (reference score A1) and the blue curve shows the mean relative score one month later (A2). The portion of the blue curve beyond the red curve indicates performance improvement between A1 and A2. Paired t-tests, significance: * P<0.05, ** P<0.01, *** P<0.001.
Fig 2.
Observed performance at one year (A3), with A1 or A2 used as the baseline, in the MIG-HD cohort.
SDMT: Symbol Digit Modalities Test; Stroop C, W and C/W: Stroop color, word and color/word interference; MDRS: Mattis Dementia Rating Scale; TMT A, B: Trail-Making Test A and B; TFC: Total Functional Capacity; IS: Independence Scale; FAS: Functional Assessment Scale. The red curve represents the baseline (reference score). The blue (or green) curve corresponds to the mean relative score one year later (A3), with A1 (or A2 for the green curve) used as the baseline. A green curve within the blue curve indicates that the decline was easier to detect if A2 was used as the baseline, rather than A1. Paired t-tests, significance: * P<0.05, ** P<0.01, *** P<0.001.
Table 2.
Predictive factors for each task.
Fig 3.
External validation of models in the RIL-HD cohort, based on Re2 and ICC.
SDMT: Symbol Digit Modalities Test; Stroop C, W and C/W: Stroop color, word and color/word interference; MDRS: Mattis Dementia Rating Scale; TMT A, B: Trail-Making Test A and B; HVLT: Hopkins Verbal Learning Task; TFC: Total Functional Capacity; IS: Independence Scale; FAS: Functional Assessment Scale. N: number of patients in the RIL-HD cohort for whom all the data required for the predictive model were available. Re2: coefficient of determination for external validation. ICC: intraclass correlation coefficient. 95% CI: 95% confidence interval. a: Re2 = -0.7. The red line represents the limit for a high-quality model (Re2 > 50% of the observed variance explained by the model).