Table 1.
Hemostasis Parameters in Transfused Serum Preparations.
Fig 1.
Plasma concentrations of (A) D-dimer, (B) F1+2, (C) TAT, and (D) PAP in healthy volunteers during and after autologous serum transfusion.
Transfusion of 50 mL serum was started at t = 0 and completed at t = 0.5 h. Data points show the median of n = 15 probands, error bars show the interquartile range. Smooth curves show best least squares fit exponential decay functions.
Table 2.
Changes of Hemostasis Parameters Induced by Serum Transfusion.
Table 3.
Elimination Kinetics of Hemostasis-related Biomarkers.
Fig 2.
Half-lives of hemostasis-related biomarkers and their corresponding reactants.
The relatively short half-lives of F1+2 and TAT qualify these biomarkers as dynamic biomarkers indicating changes in thrombin formation within hours, whereas D-dimer is a “long acting” biomarker indicating changes in fibrin degradation from day to day. The half-lives of the protease complexed serpins TAT and PAP differed markedly suggesting different elimination pathways. FMx indicates crosslinked fibrin.