Figure 1.
Flowchart for search execution.
Table 1.
Study design characteristics of included and excluded studies by type of event.
Figure 2.
The causal pathway from antipsychotic type to mortality through medical events.
The average medical event rates (per 100 person-years) were 4.7 for stroke, 0.48 for ventricular arrhythmia, 1.2 for venous thromboembolism, 2.0 for myocardial infarction, 6.2 for hip fracture, and 4.8 for pneumonia. In calculations they were scaled to units of 50-person years to approximate six-month risk.
Table 2.
Descriptions of included studies (all conducted and analyzed as cohort studies).
Table 3.
Medical event occurrence, association with antipsychotic type (FGA vs. SGA), and difference in mortality between FGAs and SGAs due to their difference in risk for the medical event.