Table 1.
Clinical characteristics of AVH patients during the acute psychotic episode (n = 9).
Figure 1.
Group effects of auditory stimulation on brain metabolism (rGMR).
Left panel: t maps show increased brain metabolism in the superior temporal cortex during the auditory stimulation condition relative to the resting condition in all participants (including patients and controls). Right panel: during auditory stimulation, patients showed increased metabolism in mesolimbic regions and decreased metabolism in fusiform gyrus compared to controls. Maps are thresholded at p = 0.005 and 10 adjacent voxels. Orange colors represent a relative increase in metabolic activity; blue colors represent a relative decrease in metabolic activity.
Table 2.
Group differences in rGMR during auditory stimulation.
Figure 2.
Functional correlations of left amygdala across participants.
Brain regions in which rGMR correlates positively (orange colors) or negatively (blue colors) with the amygdala rGMR across participants: controls (left), patients (middle), and difference between the groups (right). Compared to controls, patients had stronger correlations (orange) between the amygdala and the thalamus-hippocampus and weaker correlations (blue) with the medial prefrontal cortex across conditions. Maps are thresholded at p = 0.005 and 10 adjacent voxels.
Table 3.
Group differences in amygdalar correlations.
Figure 3.
Functional correlations of rGMR between left amygdala and posterior (auditory) thalamus in patients.
Scatterplots show positive correlations between the rGMR in the amygdala ROI and the thalamus cluster with significant group effects (Figure 2) across all three states: before treatment, in the acute phase of AVH (left panel), post-treatment at rest (middle panel), and post-treatment during auditory stimulation (right panel). Each patient is represented by the same color in the three panels.