Figure 1.
Distribution of estimated glomerular filtration rates.
A. Histogram showing the distribution of the study population according to the eGFR level at inclusion. B. Histogram showing eGFR values according to the type of kidney disease. eGFR is expressed as the mean ± sem. *p<0.05, **p<0.01, ***p<0.001 compared to glomerular disease using Student's T test; the Mann-Whitney test was used for the glomerular vs. comparison with non-specific lesions. Glom: glomerular diseases; Tub-Int: tubular and/or interstitial diseases; Vasc: vascular diseases; Non-spe: non-specific.
Table 1.
Baseline characteristics of the study cohort (n = 162).
Figure 2.
Expression patterns of proteinuria.
A, B. Best-fit slope of the linear regression between RBP and β2MG (A) and RBP and Alb (B). C, D, E. Histogram showing Alb (A), RBP (B), and IgG (C) values according to the type of kidney disease. Protein concentrations are expressed as the mean ± sem. **p<0.01, ***p<0.001 compared to glomerular disease using Student's T test; the Mann-Whitney test was used for the glomerular vs. comparison with non-specific lesions. Glom: glomerular diseases; Tub-Int: tubular and/or interstitial diseases; Vasc: vascular diseases; Non-spe: non-specific.
Table 2.
Summary of correlative data.
Figure 3.
Distribution of proteinuria according to the estimated glomerular filtration rate.
A, B, C. Histogram showing Alb (A), RBP (B), and total proteinuria (C) values according to the level of eGFR. Protein concentrations are expressed as the mean ± sem. **p<0.01, ***p<0.001 compared to eGFR <30 ml/min, using Student's T test.
Figure 4.
Correlation between the estimated glomerular filtration rate and extent of interstitial fibrosis.
A. Best-fit slope of the linear regression between eGFR and extent of fibrosis. B, C, D. Best-fit slope of the linear regression between eGFR and extent of fibrosis in glomerular disease (B), tubular disease (C), and vascular disease (D). E. Histogram of the distribution of the extent of interstitial fibrosis according to the type of kidney disease. The percentages of interstitial fibrosis are expressed as the mean ± sem. *p<0.05 compared to glomerular disease, using Student's T test; the Mann-Whitney test was used for the glomerular vs. non specific lesions comparison. Glom: glomerular diseases; Tub-Int: tubular and/or interstitial diseases; Vasc: vascular diseases; Non-spe: non-specific.
Figure 5.
Correlation between proteinuria and the extent of interstitial fibrosis.
A, B. Best-fit slope of the linear regression between RBP (A) and Alb (B) and extent of fibrosis extent.