Figure 1.
Tractography of the cingulum bundle.
Graphical rendering of tractography of the left cingulum bundle (CB) in a representative healthy control. Points 1 to 5 represent anatomical landmarks (LMs) used for sub-segmentation analysis (see Material and Methods).
Figure 2.
Delineation of the anterior cingulate cortex.
a) Medial view of the right hemisphere in a healthy control with cortical parcellation according to Desikan Killiany, using Freesurfer software. Note the division of the cingulate cortex into anterior cingulate cortex (ACC) and posterior cingulate cortex, and the further division of the ACC into a rostral anterior division (dark purple) and the caudal anterior division (light purple). b) Illustration showing the anatomical mask used on VBM rendered images to delineate the ACC.
Figure 3.
Quantitative Tractography Evaluation of the cingulum bundle.
Graphical representation of the Quantitative Tractography Evaluation (QuTE) of the cingulum bundle. Y-axis: fractional anisotropy (FA) of the left and right cingulum bundle (mean). Red color: patients with behavioral variant frontotemporal dementia, blue color: healthy controls. The central line represents the mean, fields indicate +/- 1 standard error. X-axis refers to the numbers of the anatomical landmarks used to subsegment the cingulum bundle (see Figure 1 and Material and Methods).