Table 1.
Experimental cryptosporidiosis in SCID mice: influence of inoculum size on infectivity and histopathological findings.
Figure 1.
Pattern of oocyst shedding (oocyst/g feces) of Dex-treated SCID mice.
Experimental groups were inoculated with intended doses of 1, 10, 100 and 105 oocysts. Each point represents one mouse, the lines being the geometric means of oocyst shedding per group. Only animals with oocyst shedding at a precise moment of the day are represented. None of mice infected with one oocyst released parasites until day 15 (see material and methods for oocyst shedding assessment).
Figure 2.
Gastro-intestinal neoplastic lesions in Dex-treated SCID mice infected with one oocyst of C. parvum.
A. Invasive adenocarcinoma of the antropyloric region (arrows) in a mouse 100 days P.I.. Bar = 1250 µm (hematoxylin and eosin). B. Invasive adenocarcinoma of the antropyloric region in a mouse 100 days P.I. showing parasites inside the glands (arrows). Bar = 50 µm (hematoxylin and eosin). C. Adenoma of the ileo-caecal region in a mouse 45 days P.I.. Bar = 625 µm. D. High grade intraepithelial neoplasia in the ileo-caecal region in a mouse 45 days P.I. with numerous parasites (arrow) inside the glands. Bar = 25 µm (hematoxylin and eosin).