Figure 1.
The 4,939-nt circular genome of MXPyV (A) contains putative coding regions for VP1, VP2, VP3, ST-Ag, and LT-Ag (yellow arrows). C1, C2, and C3 (gray) denote de novo assembled contigs from deep sequencing data. (B) Domains and binding motifs present in the spliced LT-Ag and ST-Ag of MXPyV.
Figure 2.
Amino acid phylogenetic analysis of MXPyV relative to other polyomaviruses.
(A) VP1, (B) VP2, (C) ST-Ag, (D) LT-Ag. Bayesian support levels are indicated at each branching point. Abbreviations: AGM, African green monkey; SV40, simian virus 40; SV12, simian virus 12; SqMPy, squirrel monkey; CaliSeaLion, California sea lion. Other abbreviations and GenBank accession numbers are described in the text. Note that Merkel cell virus (MCV) is not included in the LT-Ag phylogeny due to the presence of truncation mutations.
Figure 3.
Amino acid identities of the VP1, VP2, small T-antigen, large T-antigen of MXPyV relative to that of other polyomaviruses.
Table 1.
Results from MXPyV screening of clinical samples by RT-PCR.
Table 2.
Comparison of quantitative RT-PCR vs. PCR assays for detection of MXPyV and titers of MXPyV in stool.
Table 3.
Gastroenteritis symptoms corresponding to MXPyV-positive stool samples compared to uninfected samples in the California SIFT study.
Table 4.
Demographics of individuals who provided stool samples from the California SIFT study according to MXPyV positivity.
Figure 4.
Whole-genome sequence alignment of MXPyV relative to other recently described gut-associated polyomaviruses HPyV10 and MWPyV.