Figure 1.
Differences of cortical thickness between the baseline and two years later in aMCI.
The red/yellow showed the significantly different cortical thickness between the MCI_M1 and MCI_M2 groups. Only significantly reduced cortical thickness was found in the MCI_M2 group. The color bar indicated the vertex-wise p-value which ranged from 0 to 0.01 with the correction for multiple comparisons.
Table 1.
Brain regions demonstrating significant difference in cortical thickness between MCI_M1 and MCI_M2 groups.
Figure 2.
Differences of cortical thickness between the baseline and two years later in NC.
The colorized areas indicated the different cortical thickness between the NC_M1 and NC_M2 groups. The range and degree of atrophy in NC_M2 were sight. The p values of the vertices indicated by the color bar were corrected using the FDR correction.
Table 2.
Significant atrophy regions between NC_M1 and NC_M2 groups.
Figure 3.
Cortical thinning in aMCI compared to NC at baseline time.
The colorized areas indicated the brain regions with significantly reduced cortical thickness in aMCI compared with NC at baseline time with a correction for multiple comparisons (P<0.05, the cluster-based RFT correction).
Table 3.
Brain regions demonstrating significantly reduced cortical thickness in aMCI at baseline.
Figure 4.
Cortical thinning in aMCI compared to NC two years later.
Significant cortical thickness differences were found between aMCI and NC two years after the baseline time. The color bar indicated the cluster-wise p-value with the cluster-based RFT correction.
Table 4.
Brain regions demonstrating significantly reduced cortical thickness in aMCI two years later.
Figure 5.
Differences of atrophy rate between aMCI and normal aging over two years.
Differences of atrophy rate between aMCI subjects and normal controls were obtained using the random field theory (RFT)-based cluster analysis. The colorized areas represented the between-group differences of atrophy rate, which showed the more serious atrophy in aMCI over two years. The color bar indicated the cluster-wise p-value with the correction for multiple comparisons.
Table 5.
Differences of atrophy rate between aMCI subjects and normal people.
Figure 6.
Correlation between the decline of MMSE scores and cortical atrophy in aMCI.
The correlations at all significant vertices were positive and the color bar indicated the vertex-wise p-value with the FDR correction at a 0.01 level of significance.
Table 6.
Brain regions with significant positive correlation between cortical atrophy and the decline of MMSE scores in aMCI.