Table 1.
Cohort characteristics.
Table 2.
Adverse event frequency and duration for three different cohorts.
Figure 1.
Time to microscopically detected parasitemia by cohort.
Survival curve for four cohorts: RUNMC I (orange), RUNMC II (blue), USMMVP (interrupted grey line) and Oxford (green).
Figure 2.
Geometric mean parasite density by Q-PCR per cohort.
Three cohorts are depicted RUNMC I (orange), RUNMC II (blue) and Oxford (green).
Figure 3.
Statistics of Q-PCR parasitemia per cohort.
Peak parasitemia (A, one-way ANOVA p = 0.13), geometric mean parasitemia during the first blood stage parasite multiplication cycle, day 6.5 to 8.5 (B, one-way ANOVA p<0.001) and blood stage multiplication factor (C, one-way ANOVA p = 0.97) per cohort. Individual data is plotted, lines represent geometric means. The threshold of detection of parasites by Q-PCR was 20 parasites/ml blood. Any CT value >45 was assigned a parasitemia of 10 parasites/ml.
Figure 4.
Correlation of Q-PCR parasitemia with prepatent period.
Correlation between peak parasitemia (A) or geometric mean parasitemia during the first multiplication cycle from day 6.5 to day 8.5 (B) with prepatent period (R2 = 0.27 and −0.73, p = 0.006 and p = <0.001, respectively). Prepatent period was defined as the time between exposure to infectious mosquito bites until detection of blood stage parasites by microscopy.