N-dihydrogalactochitosan reduces mortality in a lethal mouse model of SARS-CoV-2
Fig 5
Fluorescent labeled GC (FITC-GC) administered intranasally to mice localizes to the nasal cavity and immune cell influx results in nasal concha histopathology scores.
Fluorescent images of nasal concha from mice administered (a) no FITC-GC or (b-f) 0.75% FITC-GC i.n. administered once, and euthanized 2h, 9h, 2d or 3d later. Mice in the group euthanized 3d after the first treatment were administered a second treatment (2X)1d before euthanasia. Panel (b) is at a magnification of 10X, (c-f) are at a magnification of 20X. NC is nasal conchae, T is tooth, CT is connective tissue. (g) Fluorescence measured as percent of total image area, limited to nasal mucosa. Matching symbols for each time show 2 measurements from the same mouse. (h) Nasal concha histopathology scores based on the scoring rubric in S3 Table in S1 File. N = 2 mice per time. The small group size precluded statistical assessments.